PXD037817

PXD037817 is an original dataset announced via ProteomeXchange.

Title	Comprehensive protein-expression map of ILC2 and ILC3 subsets in healthy human skin
Description	Innate lymphoid cells (ILCs) have emerged as essential players in the skin-associated immune system in health and inflammatory skin diseases. Their low numbers and lack of specific markers hampered extensive characterization and consequently resulted in limited knowledge of their protein expression. Here, we combined flow cytometry and state-of-the-art proteomics to comprehensively describe the proteins constitutively expressed by ILC2 and ILC3 subsets derived from healthy human skin and peripheral blood. We quantified 6666 proteins from skin ILC and identified 608 differentially expressed proteins in the investigated subsets. In addition to the current analyses, highlighting new functions of ILC, the ILC proteomic libraries and the proteomes of the ILC2 and ILC3 subsets will serve as valuable resources for future analyses of ILC function and are available at http://skin.science.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:27:18.079.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Julie Breinholt Kjær Sølberg
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-28 07:56:20	ID requested
1	2023-10-10 05:24:04	announced
⏵ 2	2023-11-14 08:27:18	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: ILC, proteomics, innate lymphoid cells, skin, blood

Beatrice Dyring-Andersen
contact affiliation	Department of Dermatology and Allergy Herlev-Gentofte Hospital, University of Copenhagen Hellerup, Denmark.
contact email	beatrice.dyring-andersen@regionh.dk
lab head
Julie Breinholt Kjær Sølberg
contact affiliation	Department of allergy and skin, Gentofte Hospital, Gentofte
contact email	julie.soelberg@regionh.dk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD037817

PRIDE project URI

• PRIDE
  1. PXD037817
     1. Label: PRIDE project
     2. Name: Comprehensive protein-expression map of ILC2 and ILC3 subsets in healthy human skin