PXD037816
PXD037816 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Utility of CYP2D6 copy number variants as prognostic biomarker in localized anal squamous cell carcinoma |
Description | Anal squamous cell carcinoma (ASCC) is an infrequent tumor. Since 70s, treatment of stages II-III consists on a combination of 5-fluorouracil (5FU), mitomycin C (MMC), and radiotherapy. The aim of this study is the identification of biomarkers that allow personalized treatment and improvement of therapeutic outcomes. Forty-six tumor paraffin samples from ASCC patients were analyzed by whole-exome sequencing. Single nucleotide polymorphisms and copy number variants (CNVs) were identified and their relation to disease-free survival (DFS) was studied using BRB Array Tool and Kaplan-Meier analyses. Obtained findings were validated in an independent retrospective cohort of 101 ASCC patients with stages I-III from eleven hospitals within the Multidisciplinary Spanish Digestive Cancer Group (GEMCAD) using qPCR Copy Number Assays. GEMCAD validation cohort was also analyzed using mass spectrometry proteomics to assess the biological features of these tumors. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:45:09.193.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Antje Dittmann |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2022-10-28 07:55:51 | ID requested | |
1 | 2023-04-26 00:47:21 | announced | |
⏵ 2 | 2023-11-14 08:45:17 | announced | 2023-11-14: Updated project metadata. |
Publication List
Trilla-Fuertes L, G, á, mez-Pozo A, Nogu, é M, Busquier I, Arias F, L, ó, pez-Campos F, Fern, á, ndez-Montes A, Ruiz A, Vel, á, zquez C, Mart, í, n-Bravo C, P, é, rez-Ruiz E, Asensio E, Hern, á, ndez-Yag, ü, e X, Rodrigues A, Ghanem I, L, ó, pez-Vacas R, Hafez A, Arias P, Dap, í, a I, Sol, í, s M, Dittmann A, Ramos R, Llorens C, Maurel J, Campos-Barros Á, Fresno Vara J Á, Feliu J, Utility of CYP2D6 copy number variants as prognostic biomarker in localized anal squamous cell carcinoma. Cancer, 129(16):2581-2592(2023) [pubmed] |
Keyword List
ProteomeXchange project tag: EPIC-XS |
submitter keyword: ASCC, DIA,Anal squamous cell carcinoma, FFPE, radiotherapy, 5FU, MMC, LC-MS/MS |
Contact List
Jaime Feliu | |
---|---|
contact affiliation | Molecular Oncology and Pathology Lab, Hospital Universitario La Paz-IdiPAZ, Madrid, Spain |
contact email | jaimefeliu@hotmail.com |
lab head | |
Antje Dittmann | |
contact affiliation | ETH |
contact email | antje.dittmann@gmail.com |
dataset submitter |
Full Dataset Link List
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PRIDE project URI |
Repository Record List
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