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PXD037763

PXD037763 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleComprehensive evaluation of Ubiquinol-supplemented diet effects in the 3xTg AD mice using MALDI-MSI
DescriptionAlzheimer's disease (AD) is a chronic neurodegenerative disorder, accounting for up to 75 % of all dementia cases. Although the basis of AD etiology remains unknown, oxidative stress constitutes a major driver given its intimate association, specially at prodromic stages of the disease. In this line, Ubiquinol, the reduced form of coenzyme Q10, is a well-known neuroprotective antioxidant and has demonstrated significant effects in oxidative responses of β-Amyloid aggregation, internalization, and apoptosis-induced neurodegeneration. However, full extent of Ubiquinol effects in the context of AD is not yet known in detail. In this study, we designed a new methodology based on MALDI MSI for evaluating the peptide profile of the 3xTg-AD mice model fed a Ubiquinol-supplemented diet. By adopting functional analysis tools, we observed differential functional profile in hippocampus and cortex levels after 4- or 10-m o supplementation. Therefore, we also identified ACAD9, XPO1 and EIF3A as potential protein references for the diagnosis of AD at early/late stages.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:45:53.883.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterEmilio Llanos González
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentTripleTOF 5600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-10-27 02:44:49ID requested
12023-05-10 09:08:35announced
22023-11-14 08:45:56announced2023-11-14: Updated project metadata.
Publication List
Llanos-Gonz, á, lez E, Sancho-Bielsa FJ, Fronti, ñ, á, n-Rubio J, Rabanal-Ru, í, z Y, Garc, í, a-Carpintero S, Chicano E, Ú, beda-Banon I, Flores-Cuadrado A, Gim, é, nez-Llort L, Alca, í, n FJ, Peinado JR, Dur, á, n-Prado M, Spatial and Temporal Protein Modules Signatures Associated with Alzheimer Disease in 3xTg-AD Mice Are Restored by Early Ubiquinol Supplementation. Antioxidants (Basel), 12(3):(2023) [pubmed]
Keyword List
submitter keyword: Mass spectrometry
MALDI-imaging
Alzheimer disease
Coenzyme Q10
3xTg-AD mice
Contact List
Mario Durán Prado
contact affiliationCellular Biology Department, Oxidative Stress and Neurodegeneration group, Ciudad Real Medical School, Castilla-La Mancha University
contact emailmario.duran@uclm.es
lab head
Emilio Llanos González
contact affiliationMedical School, Castilla-La Mancha University
contact emailemilio.llanos@uclm.es
dataset submitter
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Dataset FTP location
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PRIDE project URI
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