PXD037763
PXD037763 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Comprehensive evaluation of Ubiquinol-supplemented diet effects in the 3xTg AD mice using MALDI-MSI |
Description | Alzheimer's disease (AD) is a chronic neurodegenerative disorder, accounting for up to 75 % of all dementia cases. Although the basis of AD etiology remains unknown, oxidative stress constitutes a major driver given its intimate association, specially at prodromic stages of the disease. In this line, Ubiquinol, the reduced form of coenzyme Q10, is a well-known neuroprotective antioxidant and has demonstrated significant effects in oxidative responses of β-Amyloid aggregation, internalization, and apoptosis-induced neurodegeneration. However, full extent of Ubiquinol effects in the context of AD is not yet known in detail. In this study, we designed a new methodology based on MALDI MSI for evaluating the peptide profile of the 3xTg-AD mice model fed a Ubiquinol-supplemented diet. By adopting functional analysis tools, we observed differential functional profile in hippocampus and cortex levels after 4- or 10-m o supplementation. Therefore, we also identified ACAD9, XPO1 and EIF3A as potential protein references for the diagnosis of AD at early/late stages. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:45:53.883.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Emilio Llanos González |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | TripleTOF 5600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2022-10-27 02:44:49 | ID requested | |
1 | 2023-05-10 09:08:35 | announced | |
⏵ 2 | 2023-11-14 08:45:56 | announced | 2023-11-14: Updated project metadata. |
Publication List
Llanos-Gonz, á, lez E, Sancho-Bielsa FJ, Fronti, ñ, á, n-Rubio J, Rabanal-Ru, í, z Y, Garc, í, a-Carpintero S, Chicano E, Ú, beda-Banon I, Flores-Cuadrado A, Gim, é, nez-Llort L, Alca, í, n FJ, Peinado JR, Dur, á, n-Prado M, Spatial and Temporal Protein Modules Signatures Associated with Alzheimer Disease in 3xTg-AD Mice Are Restored by Early Ubiquinol Supplementation. Antioxidants (Basel), 12(3):(2023) [pubmed] |
Keyword List
submitter keyword: Mass spectrometry |
MALDI-imaging |
Alzheimer disease |
Coenzyme Q10 |
3xTg-AD mice |
Contact List
Mario Durán Prado | |
---|---|
contact affiliation | Cellular Biology Department, Oxidative Stress and Neurodegeneration group, Ciudad Real Medical School, Castilla-La Mancha University |
contact email | mario.duran@uclm.es |
lab head | |
Emilio Llanos González | |
contact affiliation | Medical School, Castilla-La Mancha University |
contact email | emilio.llanos@uclm.es |
dataset submitter |
Full Dataset Link List
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/05/PXD037763 |
PRIDE project URI |
Repository Record List
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