PXD037763

PXD037763 is an original dataset announced via ProteomeXchange.

Title	Comprehensive evaluation of Ubiquinol-supplemented diet effects in the 3xTg AD mice using MALDI-MSI
Description	Alzheimer's disease (AD) is a chronic neurodegenerative disorder, accounting for up to 75 % of all dementia cases. Although the basis of AD etiology remains unknown, oxidative stress constitutes a major driver given its intimate association, specially at prodromic stages of the disease. In this line, Ubiquinol, the reduced form of coenzyme Q10, is a well-known neuroprotective antioxidant and has demonstrated significant effects in oxidative responses of β-Amyloid aggregation, internalization, and apoptosis-induced neurodegeneration. However, full extent of Ubiquinol effects in the context of AD is not yet known in detail. In this study, we designed a new methodology based on MALDI MSI for evaluating the peptide profile of the 3xTg-AD mice model fed a Ubiquinol-supplemented diet. By adopting functional analysis tools, we observed differential functional profile in hippocampus and cortex levels after 4- or 10-m o supplementation. Therefore, we also identified ACAD9, XPO1 and EIF3A as potential protein references for the diagnosis of AD at early/late stages.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:45:53.883.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Emilio Llanos González
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-27 02:44:49	ID requested
1	2023-05-10 09:08:35	announced
⏵ 2	2023-11-14 08:45:56	announced	2023-11-14: Updated project metadata.

Llanos-Gonz, á, lez E, Sancho-Bielsa FJ, Fronti, ñ, á, n-Rubio J, Rabanal-Ru, í, z Y, Garc, í, a-Carpintero S, Chicano E, Ú, beda-Banon I, Flores-Cuadrado A, Gim, é, nez-Llort L, Alca, í, n FJ, Peinado JR, Dur, á, n-Prado M, Spatial and Temporal Protein Modules Signatures Associated with Alzheimer Disease in 3xTg-AD Mice Are Restored by Early Ubiquinol Supplementation. Antioxidants (Basel), 12(3):(2023) [pubmed]

submitter keyword: Mass spectrometry

MALDI-imaging

Alzheimer disease

Coenzyme Q10

3xTg-AD mice

Mario Durán Prado
contact affiliation	Cellular Biology Department, Oxidative Stress and Neurodegeneration group, Ciudad Real Medical School, Castilla-La Mancha University
contact email	mario.duran@uclm.es
lab head
Emilio Llanos González
contact affiliation	Medical School, Castilla-La Mancha University
contact email	emilio.llanos@uclm.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/05/PXD037763

PRIDE project URI

• PRIDE
  1. PXD037763
     1. Label: PRIDE project
     2. Name: Comprehensive evaluation of Ubiquinol-supplemented diet effects in the 3xTg AD mice using MALDI-MSI