PXD037742

PXD037742 is an original dataset announced via ProteomeXchange.

Title	Inhibition of fatty acid synthesis by Pristanic moieties elevates MHC II to potentiate immune detection and destruction of cancer
Description	Cancer is a leading cause of human disease. Avoiding cancer immune surveillance and metabolic reprogramming are the two newly added hallmarks of cancer, but requiring more mechanistic understanding and effective coping strategies. Our data show that pristanic moieties, including pristane, a natural immunostimulant inspired by the diet of cancer resistant whales, and its optimized derivatives, elevate MHC II expression to potentiate immune detection and cancer destruction by binding to the substrate pocket in the MAT domain of FASN and inhibiting fatty acid synthesis. This study improves our mechanistic understanding of immunity and metabolism in cancer as well as provides metabolic immunotherapies by revealing the critical role of metabolism-silenced MHC II exerted by pristane moieties in cancer immune detection.
HostingRepository	iProX
AnnounceDate	2022-10-26
AnnouncementXML	Submission_2022-10-26_19:02:14.176.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ling Huang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-26 19:01:14	ID requested
⏵ 1	2022-10-26 19:02:14	announced

Dataset with its publication pending

submitter keyword: Pristanic moieties, FASN, MHC II, immune detection, breast cancer

Liming Chen
contact affiliation	Nanjing Normal University
contact email	chenliming1981@njnu.deu.cn
lab head
Ling Huang
contact affiliation	Nanjing Normal University
contact email	huangling950825@163.com
dataset submitter

iProX dataset URI