PXD037729

PXD037729 is an original dataset announced via ProteomeXchange.

Title	Chemical crosslinking and mass spectrometry of the human Rix1 complex
Description	PELP1 is a scaffold protein with diverse cellular functions including its role as the central scaffold for the human Rix1 complex (PELP1, WDR18, TEX10, and SENP3). We have reconstituted the mammalian Rix1 complex and identified a sub-complex made of the conserved Rix1 domain of PELP1 and the WDR18 protein. Moreover, using Cryo-electron microscopy (cryo-EM) and aided by chemical crosslinking and mass spectrometry, we determined the structure of this PELP1 Rix1 domain complexed with WDR18.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:43:23.596.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jason Williams
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-26 01:19:50	ID requested
1	2023-03-11 10:20:31	announced
⏵ 2	2023-11-14 08:43:24	announced	2023-11-14: Updated project metadata.

Gordon J, Chapus FL, Viverette EG, Williams JG, Deterding LJ, Krahn JM, Borgnia MJ, Rodriguez J, Warren AJ, Stanley RE, Cryo-EM reveals the architecture of the PELP1-WDR18 molecular scaffold. Nat Commun, 13(1):6783(2022) [pubmed]

submitter keyword: Q-Exactive, LC-MS,Rix1, Protein Prospector, PELP1, BS3, crosslinking

Jason G. Williams
contact affiliation	Mass Spectrometry Research and Support Group National Institute of Environmental Health Sciences 111 TW Alexander Drive MD F0-04 Research Triangle Park, North Carolina 27709
contact email	willia56@niehs.nih.gov
lab head
Jason Williams
contact affiliation	National Institute of Environmental Health Sciences
contact email	willia56@niehs.nih.gov
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD037729

PRIDE project URI

• PRIDE
  1. PXD037729
     1. Label: PRIDE project
     2. Name: Chemical crosslinking and mass spectrometry of the human Rix1 complex