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PXD037654

PXD037654 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomics of cervical mucus in natural and stimulated cycle
DescriptionCervical mucus is a viscous fluid functioning as a uterine cervix plug. It is formed and produced by cervical glands located in the cervix. During ovulation, cervical mucus starts to become less viscous, which is a good window for non-invasive sampling. Our study focuses on the proteomic characterization of cervical mucus, which may thus act as a non-invasively acquired source of biomarkers for diseases and physiological conditions of the female genital tract. Our study aimed at two aims - the first is to optimize a proteomic workflow of cervical mucus processing. The second aim is to assess differences in the proteomic composition of cervical mucus in natural ovulatory cycles and IVF cycles with controlled ovarian hyperstimulation. The sampling was done in cooperation with women undergoing intrauterine insemination in a natural ovulatory cycle and women undergoing controlled ovarian hyperstimulation for IVF. The optimization of proteomic workflow including an analysis on an Orbitrap mass spectrometer was performed. The results revealed the protein composition and the differences of the cervical mucus between natural and stimulated uterus.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:28:47.632.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD037654
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterTomáš Oždian
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-10-24 00:57:24ID requested
12023-03-10 15:55:08announced
22023-11-14 08:28:48announced2023-11-14: Updated project metadata.
Publication List
10.6019/PXD037654;
O, ž, dian T, Vodi, č, ka J, Dost, á, l J, Holub D, V, á, clavkov, á J, Je, š, eta M, Hamern, í, kov, á B, Kou, ř, ilov, á P, Malchar O, Dvo, ř, á, k V, Hejtm, á, nek P, Sobkov, á K, Ventruba P, Pilka R, D, ž, ub, á, k P, Hajd, ú, ch M, Proteome Mapping of Cervical Mucus and Its Potential as a Source of Biomarkers in Female Tract Disorders. Int J Mol Sci, 24(2):(2023) [pubmed]
Keyword List
submitter keyword: cervix, fluid, cancer, endometrioisis, proteomics, endometrium, receptivity, mucus, biomarker
Contact List
Marián Hajdúch
contact affiliationInstitute of Molecular and Translational Medicine Faculty of Medicine and Dentistry, Palacky University in Olomouc Hněvotínská 5, Olomouc, 775 15 Cyech Republic
contact emailmarian.hajduch@upol.cz
lab head
Tomáš Oždian
contact affiliationLaboratory of Experimental Medicine, Institute of Molecular and Translational Medicine Faculty of medicine, Palacky University
contact emailtomas.ozdian@upol.cz
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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