PXD037654
PXD037654 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomics of cervical mucus in natural and stimulated cycle |
Description | Cervical mucus is a viscous fluid functioning as a uterine cervix plug. It is formed and produced by cervical glands located in the cervix. During ovulation, cervical mucus starts to become less viscous, which is a good window for non-invasive sampling. Our study focuses on the proteomic characterization of cervical mucus, which may thus act as a non-invasively acquired source of biomarkers for diseases and physiological conditions of the female genital tract. Our study aimed at two aims - the first is to optimize a proteomic workflow of cervical mucus processing. The second aim is to assess differences in the proteomic composition of cervical mucus in natural ovulatory cycles and IVF cycles with controlled ovarian hyperstimulation. The sampling was done in cooperation with women undergoing intrauterine insemination in a natural ovulatory cycle and women undergoing controlled ovarian hyperstimulation for IVF. The optimization of proteomic workflow including an analysis on an Orbitrap mass spectrometer was performed. The results revealed the protein composition and the differences of the cervical mucus between natural and stimulated uterus. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:28:47.632.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD037654 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Tomáš Oždian |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2022-10-24 00:57:24 | ID requested | |
1 | 2023-03-10 15:55:08 | announced | |
⏵ 2 | 2023-11-14 08:28:48 | announced | 2023-11-14: Updated project metadata. |
Publication List
10.6019/PXD037654; |
O, ž, dian T, Vodi, č, ka J, Dost, á, l J, Holub D, V, á, clavkov, á J, Je, š, eta M, Hamern, í, kov, á B, Kou, ř, ilov, á P, Malchar O, Dvo, ř, á, k V, Hejtm, á, nek P, Sobkov, á K, Ventruba P, Pilka R, D, ž, ub, á, k P, Hajd, ú, ch M, Proteome Mapping of Cervical Mucus and Its Potential as a Source of Biomarkers in Female Tract Disorders. Int J Mol Sci, 24(2):(2023) [pubmed] |
Keyword List
submitter keyword: cervix, fluid, cancer, endometrioisis, proteomics, endometrium, receptivity, mucus, biomarker |
Contact List
Marián Hajdúch | |
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contact affiliation | Institute of Molecular and Translational Medicine Faculty of Medicine and Dentistry, Palacky University in Olomouc Hněvotínská 5, Olomouc, 775 15 Cyech Republic |
contact email | marian.hajduch@upol.cz |
lab head | |
Tomáš Oždian | |
contact affiliation | Laboratory of Experimental Medicine, Institute of Molecular and Translational Medicine Faculty of medicine, Palacky University |
contact email | tomas.ozdian@upol.cz |
dataset submitter |
Full Dataset Link List
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD037654 |
PRIDE project URI |
Repository Record List
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