PXD037646
PXD037646 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Mechanism study of acetylshikonin on attenuation with cardiomyopathy of diabetic mice via mTOR signaling pathway |
Description | Diabetic cardiomyopathy (DCM) is a complication of diabetes, which may be associated with a great risk of mortality. Comprehensively understanding the effects and mechanisms of acetylshikonin (AS) on the attenuation of DCM will be helpful for the innovative drug investigation and clinical application. This study aimed to explore the possible links and signaling pathways between AS and DCM. A cohort of diabetic mice was established based on disease model (Model, AS, Control groups), and their serum samples were collected for non-targeted metabolomics. The high resolution mass spectrometry data among the three groups were analyzed by combining multivariate and univariate statistical methods. The differential metabolites and altered metabolic pathways were screened out and identified by examining the Kyoto Encyclopedia of Genes and Genomes database, respectively. |
HostingRepository | iProX |
AnnounceDate | 2022-10-23 |
AnnouncementXML | Submission_2022-10-23_21:14:24.943.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yunpeng Bai |
SpeciesList | scientific name: Mus sp.; NCBI TaxID: 10095; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2022-10-23 21:13:05 | ID requested | |
⏵ 1 | 2022-10-23 21:14:25 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Diabetic cardiomyopathy, acetylshikonin, diabetic mice, untargeted metabolomics, mTOR signaling pathway |
Contact List
Wendong Huang | |
---|---|
contact affiliation | Maoming People's Hospital |
contact email | huangwendong418@126.com |
lab head | |
Yunpeng Bai | |
contact affiliation | Maoming People's Hospital |
contact email | 973287422@qq.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |