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PXD037646

PXD037646 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMechanism study of acetylshikonin on attenuation with cardiomyopathy of diabetic mice via mTOR signaling pathway
DescriptionDiabetic cardiomyopathy (DCM) is a complication of diabetes, which may be associated with a great risk of mortality. Comprehensively understanding the effects and mechanisms of acetylshikonin (AS) on the attenuation of DCM will be helpful for the innovative drug investigation and clinical application. This study aimed to explore the possible links and signaling pathways between AS and DCM. A cohort of diabetic mice was established based on disease model (Model, AS, Control groups), and their serum samples were collected for non-targeted metabolomics. The high resolution mass spectrometry data among the three groups were analyzed by combining multivariate and univariate statistical methods. The differential metabolites and altered metabolic pathways were screened out and identified by examining the Kyoto Encyclopedia of Genes and Genomes database, respectively.
HostingRepositoryiProX
AnnounceDate2022-10-23
AnnouncementXMLSubmission_2022-10-23_21:14:24.943.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYunpeng Bai
SpeciesList scientific name: Mus sp.; NCBI TaxID: 10095;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-10-23 21:13:05ID requested
12022-10-23 21:14:25announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Diabetic cardiomyopathy, acetylshikonin, diabetic mice, untargeted metabolomics, mTOR signaling pathway
Contact List
Wendong Huang
contact affiliationMaoming People's Hospital
contact emailhuangwendong418@126.com
lab head
Yunpeng Bai
contact affiliationMaoming People's Hospital
contact email973287422@qq.com
dataset submitter
Full Dataset Link List
iProX dataset URI