PXD037632 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Comparative single-cell transcriptional and proteomic atlas of clinical-grade injectable mesenchymal source tissues |
Description | Bone marrow aspirate concentrate (BMAC) and adipose-derived stromal vascular fraction (ADSVF) are the most marketed stem cell therapies to treat a variety of conditions in the general population and elite athletes. Both tissues have been used interchangeably clinically even though their detailed composition, heterogeneity, and mechanisms of action have neither been rigorously inventoried nor compared. This lack of information has prevented investigations into ideal dosages and has facilitated anecdata and misinformation. Here, we analyzed single-cell transcriptomes, proteomes, and flow cytometry profiles from paired clinical-grade BMAC and ADSVF. This comparative transcriptional atlas challenges the prevalent notion that there is one therapeutic cell type present in both tissues. We also provide data of surface markers that may enable isolation and investigation of cell (sub)populations. Furthermore, the proteome atlas highlights intertissue and interpatient heterogeneity of injected proteins with potentially regenerative or immunomodulatory capacities. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:51:26.748.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Samuel Ward |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-10-20 13:52:00 | ID requested | |
1 | 2024-07-25 10:11:10 | announced | |
⏵ 2 | 2024-10-22 06:51:27 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
submitter keyword: Human, LC-MSMS, bone marrow, adipose, BMAC, ADSVF |
Contact List
Samuel Richard |
contact affiliation | Professor, Departments of Orthopaedic Surgery, Radiology, and Bioengineering Vice Chair of Research and Innovation (Orthopaedic Surgery) UC San Diego 9500 Gilman Drive (0863) La Jolla, CA 92093-0863 USA |
contact email | s1ward@health.ucsd.edu |
lab head | |
Samuel Ward |
contact affiliation | UC San Diego |
contact email | s1ward@health.ucsd.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/07/PXD037632 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD037632
- Label: PRIDE project
- Name: Comparative single-cell transcriptional and proteomic atlas of clinical-grade injectable mesenchymal source tissues