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PXD037632

PXD037632 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleComparative single-cell transcriptional and proteomic atlas of clinical-grade injectable mesenchymal source tissues
DescriptionBone marrow aspirate concentrate (BMAC) and adipose-derived stromal vascular fraction (ADSVF) are the most marketed stem cell therapies to treat a variety of conditions in the general population and elite athletes. Both tissues have been used interchangeably clinically even though their detailed composition, heterogeneity, and mechanisms of action have neither been rigorously inventoried nor compared. This lack of information has prevented investigations into ideal dosages and has facilitated anecdata and misinformation. Here, we analyzed single-cell transcriptomes, proteomes, and flow cytometry profiles from paired clinical-grade BMAC and ADSVF. This comparative transcriptional atlas challenges the prevalent notion that there is one therapeutic cell type present in both tissues. We also provide data of surface markers that may enable isolation and investigation of cell (sub)populations. Furthermore, the proteome atlas highlights intertissue and interpatient heterogeneity of injected proteins with potentially regenerative or immunomodulatory capacities.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:51:26.748.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSamuel Ward
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-10-20 13:52:00ID requested
12024-07-25 10:11:10announced
22024-10-22 06:51:27announced2024-10-22: Updated project metadata.
Publication List
10.1126/SCIADV.ADN2831;
Keyword List
submitter keyword: Human, LC-MSMS, bone marrow, adipose, BMAC, ADSVF
Contact List
Samuel Richard
contact affiliationProfessor, Departments of Orthopaedic Surgery, Radiology, and Bioengineering Vice Chair of Research and Innovation (Orthopaedic Surgery) UC San Diego 9500 Gilman Drive (0863) La Jolla, CA 92093-0863 USA
contact emails1ward@health.ucsd.edu
lab head
Samuel Ward
contact affiliationUC San Diego
contact emails1ward@health.ucsd.edu
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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