PXD037618

PXD037618 is an original dataset announced via ProteomeXchange.

Title	G3BP1-dependent suppression of polyglutamine aggregation in Huntington’s models and its failure upon stress granule formation
Description	To define the interactome of huntingtin protein (HTT) in human neurons, we assessed interactors of HTT with coimmunoprecipitation experiments with huntingtin antibody or polyqlutamine antibody (it only recognizes mutant huntingtin protein with abnormal polyqlutamine expansion) in striatal neurons differentiated from control and patient-derived iPSC lines (HD-iPSCs). GFP antibody used as a negative control.
HostingRepository	PRIDE
AnnounceDate	2022-12-02
AnnouncementXML	Submission_2022-12-02_04:22:52.694.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	PreranaWagle
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-20 13:28:39	ID requested
⏵ 1	2022-12-02 04:22:53	announced

Dataset with its publication pending

submitter keyword: stress granule,huntington’s disease

DavidVilchez
contact affiliation	University of Cologne, Germany
contact email	dvilchez@uni-koeln.de
lab head
PreranaWagle
contact affiliation	CECAD Research Center
contact email	proteomics-facility@uni-koeln.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/12/PXD037618

PRIDE project URI

• PRIDE
  1. PXD037618
     1. Label: PRIDE project
     2. Name: G3BP1-dependent suppression of polyglutamine aggregation in Huntington’s models and its failure upon stress granule formation