PXD037593

PXD037593 is an original dataset announced via ProteomeXchange.

Title	Proliferation, migration and inflammation-related signaling pathways activated in THBS4-stimulated keratinocytes characterize both wound healing and atopic dermatitis
Description	Atopic dermatitis, which is a common inflammatory skin disease characterized by persistent epidermal barrier dysfunction, is a systemic health burden reducing overall quality of life of the person. Recently, we showed that the nonstructural extracellular matrix molecule Thrombospondin-4 (THBS4) was upregulated in psoriatic skin lesions by more than 2-fold. In addition, THBS4 contributed to both skin regeneration and wound healing in vitro and in vivo. In the present work we found that THBS4 is also abundantly expressed in atopic dermatitis (AD) patient skin biopsies. By using a proteotransciptomic approach we show that stimulation of primary keratinocytes with THBS4 activates multiple factors, including inflammation, migration, proliferation, keratinocyte differentiation, by which THBS4 could participate in AD progression and contribute to the wound healing process.
HostingRepository	PRIDE
AnnounceDate	2025-03-29
AnnouncementXML	Submission_2025-03-29_06:22:39.376.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD037593
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Mariliis Klaas
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-20 02:17:28	ID requested
⏵ 1	2025-03-29 06:22:40	announced

M, ä, emets-Allas K, Klaas M, C, á, rdenas-Le, ó, n CG, Arak T, Kankuri E, Jaks V, Stimulation with THBS4 activates pathways that regulate proliferation, migration and inflammation in primary human keratinocytes. Biochem Biophys Res Commun, 642():97-106(2023) [pubmed]

10.1016/j.bbrc.2022.12.052;

10.6019/PXD037593;

submitter keyword: THBS4, thrombospondin-4, skin,Keratinocytes, atopic dermatitis

Viljar Jaks
contact affiliation	Institute of Molecular and Cell Biology, University of Tartu, Riia 23b, 51010, Tartu, Estonia
contact email	viljar.jaks@ut.ee
lab head
Mariliis Klaas
contact affiliation	University of Tartu
contact email	mariliis.klaas@ut.ee
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/03/PXD037593

PRIDE project URI

• PRIDE
  1. PXD037593
     1. Label: PRIDE project
     2. Name: Proliferation, migration and inflammation-related signaling pathways activated in THBS4-stimulated keratinocytes characterize both wound healing and atopic dermatitis