PXD037593 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proliferation, migration and inflammation-related signaling pathways activated in THBS4-stimulated keratinocytes characterize both wound healing and atopic dermatitis |
Description | Atopic dermatitis, which is a common inflammatory skin disease characterized by persistent epidermal barrier dysfunction, is a systemic health burden reducing overall quality of life of the person. Recently, we showed that the nonstructural extracellular matrix molecule Thrombospondin-4 (THBS4) was upregulated in psoriatic skin lesions by more than 2-fold. In addition, THBS4 contributed to both skin regeneration and wound healing in vitro and in vivo. In the present work we found that THBS4 is also abundantly expressed in atopic dermatitis (AD) patient skin biopsies. By using a proteotransciptomic approach we show that stimulation of primary keratinocytes with THBS4 activates multiple factors, including inflammation, migration, proliferation, keratinocyte differentiation, by which THBS4 could participate in AD progression and contribute to the wound healing process. |
HostingRepository | PRIDE |
AnnounceDate | 2025-03-29 |
AnnouncementXML | Submission_2025-03-29_06:22:39.376.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD037593 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Mariliis Klaas |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-10-20 02:17:28 | ID requested | |
⏵ 1 | 2025-03-29 06:22:40 | announced | |
Publication List
M, ä, emets-Allas K, Klaas M, C, á, rdenas-Le, ó, n CG, Arak T, Kankuri E, Jaks V, Stimulation with THBS4 activates pathways that regulate proliferation, migration and inflammation in primary human keratinocytes. Biochem Biophys Res Commun, 642():97-106(2023) [pubmed] |
10.1016/j.bbrc.2022.12.052; |
10.6019/PXD037593; |
Keyword List
submitter keyword: THBS4, thrombospondin-4, skin,Keratinocytes, atopic dermatitis |
Contact List
Viljar Jaks |
contact affiliation | Institute of Molecular and Cell Biology, University of Tartu, Riia 23b, 51010, Tartu, Estonia |
contact email | viljar.jaks@ut.ee |
lab head | |
Mariliis Klaas |
contact affiliation | University of Tartu |
contact email | mariliis.klaas@ut.ee |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD037593
- Label: PRIDE project
- Name: Proliferation, migration and inflammation-related signaling pathways activated in THBS4-stimulated keratinocytes characterize both wound healing and atopic dermatitis