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PXD037593

PXD037593 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProliferation, migration and inflammation-related signaling pathways activated in THBS4-stimulated keratinocytes characterize both wound healing and atopic dermatitis
DescriptionAtopic dermatitis, which is a common inflammatory skin disease characterized by persistent epidermal barrier dysfunction, is a systemic health burden reducing overall quality of life of the person. Recently, we showed that the nonstructural extracellular matrix molecule Thrombospondin-4 (THBS4) was upregulated in psoriatic skin lesions by more than 2-fold. In addition, THBS4 contributed to both skin regeneration and wound healing in vitro and in vivo. In the present work we found that THBS4 is also abundantly expressed in atopic dermatitis (AD) patient skin biopsies. By using a proteotransciptomic approach we show that stimulation of primary keratinocytes with THBS4 activates multiple factors, including inflammation, migration, proliferation, keratinocyte differentiation, by which THBS4 could participate in AD progression and contribute to the wound healing process.
HostingRepositoryPRIDE
AnnounceDate2025-03-29
AnnouncementXMLSubmission_2025-03-29_06:22:39.376.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD037593
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterMariliis Klaas
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-10-20 02:17:28ID requested
12025-03-29 06:22:40announced
Publication List
M, ä, emets-Allas K, Klaas M, C, á, rdenas-Le, ó, n CG, Arak T, Kankuri E, Jaks V, Stimulation with THBS4 activates pathways that regulate proliferation, migration and inflammation in primary human keratinocytes. Biochem Biophys Res Commun, 642():97-106(2023) [pubmed]
10.1016/j.bbrc.2022.12.052;
10.6019/PXD037593;
Keyword List
submitter keyword: THBS4, thrombospondin-4, skin,Keratinocytes, atopic dermatitis
Contact List
Viljar Jaks
contact affiliationInstitute of Molecular and Cell Biology, University of Tartu, Riia 23b, 51010, Tartu, Estonia
contact emailviljar.jaks@ut.ee
lab head
Mariliis Klaas
contact affiliationUniversity of Tartu
contact emailmariliis.klaas@ut.ee
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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