PXD037573 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Phosphoproteomic profiling highlights CDC42 and CDK2 as key players in the regulation of the TGF-β pathway in ALMS1 and BBS1. |
| Description | Using genomic editing with CRISPR-CAS9 and phosphoproteomics we have studied the TGF-β signalling pathway in knock-out (KO) models for ALMS1 and BBS1 genes. We have developed a network diffusion-based analysis pipeline to expand the data initially obtained and to be able to determine which processes were deregulated in the TGF-β pathway. Finally, we have analysed protein-protein interactions to prioritise candidate genes in the regulation of the TGF-β pathway in Alström and Bardet Biedl syndrome. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-17 |
| AnnouncementXML | Submission_2025-11-16_16:05:31.721.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Brais Bea Mascato |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2022-10-19 03:11:53 | ID requested | |
| ⏵ 1 | 2025-11-16 16:05:32 | announced | |
Publication List
| Bea-Mascato B, Giudice G, Pinheiro-de-Sousa I, Solarat C, Barbeito P, Petsalaki E, Valverde D, pathway in ALMS1 and BBS1 knockout models. Sci Rep, 15(1):38710(2025) [pubmed] |
| 10.1038/s41598-025-22584-0; |
Keyword List
| submitter keyword: ciliopathies, TGF-β,ALMS1, Bardet-Biedl syndrome., Alström syndrome, phosphoproteomics, BBS1 |
Contact List
| Brais Bea-Mascato |
|---|
| contact affiliation | University of Vigo |
| contact email | b.mascat@gmail.com |
| lab head | |
| Brais Bea Mascato |
|---|
| contact affiliation | University of Vigo |
| contact email | b.mascat@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD037573 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD037573
- Label: PRIDE project
- Name: Phosphoproteomic profiling highlights CDC42 and CDK2 as key players in the regulation of the TGF-β pathway in ALMS1 and BBS1.
