PXD037526 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic analysis of mitochondria from Huntington's Disease patient iPSC-derived neurons |
Description | Huntington's disease is caused by an expanded CAG repeat in the huntingtin gene, yeilding a Huntingtin protein with an expanded polyglutamine tract. Patient-derived induced pluripotent stem cells (iPSCs) can help understand disease; however, defining pathological biomarkers in challanging. Here we used LC-MS/MS to determine differences in mitochondrial proteome between iPSC-derived neurons from healthy donors and Huntington's disease patients. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_07:37:34.913.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Ranen Aviner |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-10-18 08:02:09 | ID requested | |
1 | 2023-02-10 08:04:59 | announced | |
⏵ 2 | 2023-11-14 07:37:38 | announced | 2023-11-14: Updated project metadata. |
Publication List
Wu GH, Smith-Geater C, Galaz-Montoya JG, Gu Y, Gupte SR, Aviner R, Mitchell PG, Hsu J, Miramontes R, Wang KQ, Geller NR, Hou C, Danita C, Joubert LM, Schmid MF, Yeung S, Frydman J, Mobley W, Wu C, Thompson LM, Chiu W, CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons. Nat Commun, 14(1):692(2023) [pubmed] |
Keyword List
submitter keyword: LC-MS/MS, Huntington's disease, mitochondria, neurodegeneration |
Contact List
Ranen Aviner |
contact affiliation | Chan Zuckerberg Biohub |
contact email | ranen.aviner@czbiohub.org |
lab head | |
Ranen Aviner |
contact affiliation | Chan Zuckerberg Biohub |
contact email | ranen.aviner@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/02/PXD037526 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD037526
- Label: PRIDE project
- Name: Proteomic analysis of mitochondria from Huntington's Disease patient iPSC-derived neurons