<<< Full experiment listing

PXD037374

PXD037374 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleBiochemical and Structural Basif for Differential Inhibitor Sensitivity of EGFR with Distinct Exon 19 Mutaions
DescriptionTyrosine kinase inhibitors (TKIs) are used to treat non-small cell lung cancers (NSCLC) driven by epidermal growth factor receptor (EGFR) mutations in the tyrosine kinase domain (TKD). We studied structural basis of differential TKI sensitivity among EGFR exon 19 mutants by HDX-MS.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:43:06.532.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYuko Tsutsui
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentSynapt MS
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-10-13 14:37:43ID requested
12023-03-11 06:16:59announced
22023-11-14 08:43:14announced2023-11-14: Updated project metadata.
Publication List
van Alderwerelt van Rosenburgh IK, Lu DM, Grant MJ, Stayrook SE, Phadke M, Walther Z, Goldberg SB, Politi K, Lemmon MA, Ashtekar KD, Tsutsui Y, Biochemical and structural basis for differential inhibitor sensitivity of EGFR with distinct exon 19 mutations. Nat Commun, 13(1):6791(2022) [pubmed]
Keyword List
submitter keyword: Exon 19,HDX-MS, EGFR
Contact List
Yuko Tsutsui
contact affiliationYale cancer biology institute
contact emailyuko.tsutsui@yale.edu
lab head
Yuko Tsutsui
contact affiliationYale Cancer Biology Institute
contact emailyuko.tsutsui@yale.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD037374
PRIDE project URI
Repository Record List
[ + ]