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PXD037373

PXD037373 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTyphoid toxin hijacks Wnt5a to potentiate TGFβ-mediated senescence and Salmonella infection
DescriptionDamage to our genome causes acute senescence in mammalian cells, which undergo growth arrest and release a secretome that elicits cell cycle arrest in bystander cells through the senescence-associated secretory phenotype (SASP). Thus, acute senescence is a powerful tumour suppressor. Salmonella enterica hijacks senescence through its typhoid toxin, which usurps unidentified factors in the stress secretome of senescent cells to mediate intracellular infections. Here, transcriptomics of toxin-induced senescent cells (txSCs) and proteomics of their secretome identified secreted ligands that activate the TGFβ pathway through SMAD transcription factors. The ligand Wnt5a established a self-amplifying positive feedback loop driving TGFβ signalling, which enforced autocrine senescence in txSCs and paracrine senescence in naive bystander cells by activation of DDRs. Wnt5a and GDF15 increased host cell susceptibility to infection. The study reveals how an innate defence against cancer is co-opted by a bacterial pathogen to cause widespread damage and mediate infections.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:02:48.311.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMark Collins
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentLTQ Orbitrap Elite
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-10-13 14:37:22ID requested
12023-09-07 04:43:13announced
22024-10-22 06:02:48announced2024-10-22: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Salmonella enterica, senescence, secretome
Contact List
Mark Collins
contact affiliationSchool of Biosciences University of Sheffield Firth Court, Western Bank Sheffield, S10 2TN United Kingdom
contact emailmark.collins@sheffield.ac.uk
lab head
Mark Collins
contact affiliationUniversity of Sheffield
contact emailmark.collins@sheffield.ac.uk
dataset submitter
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Dataset FTP location
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PRIDE project URI
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