PXD037371 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Global profiling of protein lysine lactylation in hepatocellular carcinoma |
Description | Hepatocellular carcinoma (HCC) is one of the most common types of tumors in adults, with an estimated 740,000 people dying every year. The characteristics of lactic acid protein modifications in HCC remain unknown. Our research team, through the whole protein high flux lactic acid group, study analyses 3 cases of normal liver tissue, 3 cases were followed up for 3 years not metastatic HCC tissue, 3 cases of HCC metastasis tumors that spread to the lungs, has presented the integrity of the generation of HCC and lung metastasis lactic acid modified map, in order to find protein lactate modification targets related to HCC formation and lung metastasis in the future. Protein lactation (Kla) is a novel type of PTM discovered in 2019. Lactate, the end-product of glycolysis, is both metabolite and a signaling molecule. Moreover, studies have shown that lactic acid serves as both an energy source for tumor tissues and mediates histone lysine lactation as a modification substrate. Protein lactate modification has been shown to play a role in inflammation, neurodevelopment, and the occurrence and development of tumors |
HostingRepository | PRIDE |
AnnounceDate | 2025-04-07 |
AnnouncementXML | Submission_2025-04-07_01:49:46.621.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Xianliang Ma |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-10-13 14:36:17 | ID requested | |
⏵ 1 | 2025-04-07 01:49:47 | announced | |
Publication List
Hong H, Chen X, Wang H, Gu X, Yuan Y, Zhang Z, Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma. Proteomics, 23(9):e2200432(2023) [pubmed] |
10.1002/pmic.202200432; |
Keyword List
submitter keyword: lysine lactylation |
HCC |
post-translational modification |
biological process |
protein modification omics |
Contact List
Yin Yuan |
contact affiliation | Department of Hepatobiliary Surgery of the affiliated Taizhou People's Hospital of Nanjing Medical University, 225300 Taizhou, Jiangsu Province, China |
contact email | 61736144@qq.com |
lab head | |
Xianliang Ma |
contact affiliation | Micrometer Biotech |
contact email | maxianliangyxz@163.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD037371
- Label: PRIDE project
- Name: Global profiling of protein lysine lactylation in hepatocellular carcinoma