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PXD037371

PXD037371 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleGlobal profiling of protein lysine lactylation in hepatocellular carcinoma
DescriptionHepatocellular carcinoma (HCC) is one of the most common types of tumors in adults, with an estimated 740,000 people dying every year. The characteristics of lactic acid protein modifications in HCC remain unknown. Our research team, through the whole protein high flux lactic acid group, study analyses 3 cases of normal liver tissue, 3 cases were followed up for 3 years not metastatic HCC tissue, 3 cases of HCC metastasis tumors that spread to the lungs, has presented the integrity of the generation of HCC and lung metastasis lactic acid modified map, in order to find protein lactate modification targets related to HCC formation and lung metastasis in the future. Protein lactation (Kla) is a novel type of PTM discovered in 2019. Lactate, the end-product of glycolysis, is both metabolite and a signaling molecule. Moreover, studies have shown that lactic acid serves as both an energy source for tumor tissues and mediates histone lysine lactation as a modification substrate. Protein lactate modification has been shown to play a role in inflammation, neurodevelopment, and the occurrence and development of tumors
HostingRepositoryPRIDE
AnnounceDate2025-04-07
AnnouncementXMLSubmission_2025-04-07_01:49:46.621.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterXianliang Ma
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-10-13 14:36:17ID requested
12025-04-07 01:49:47announced
Publication List
Hong H, Chen X, Wang H, Gu X, Yuan Y, Zhang Z, Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma. Proteomics, 23(9):e2200432(2023) [pubmed]
10.1002/pmic.202200432;
Keyword List
submitter keyword: lysine lactylation
HCC
post-translational modification
biological process
protein modification omics
Contact List
Yin Yuan
contact affiliationDepartment of Hepatobiliary Surgery of the affiliated Taizhou People's Hospital of Nanjing Medical University, 225300 Taizhou, Jiangsu Province, China
contact email61736144@qq.com
lab head
Xianliang Ma
contact affiliationMicrometer Biotech
contact emailmaxianliangyxz@163.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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