PXD037371

PXD037371 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Global profiling of protein lysine lactylation in hepatocellular carcinoma
Description	Hepatocellular carcinoma (HCC) is one of the most common types of tumors in adults, with an estimated 740,000 people dying every year. The characteristics of lactic acid protein modifications in HCC remain unknown. Our research team, through the whole protein high flux lactic acid group, study analyses 3 cases of normal liver tissue, 3 cases were followed up for 3 years not metastatic HCC tissue, 3 cases of HCC metastasis tumors that spread to the lungs, has presented the integrity of the generation of HCC and lung metastasis lactic acid modified map, in order to find protein lactate modification targets related to HCC formation and lung metastasis in the future. Protein lactation (Kla) is a novel type of PTM discovered in 2019. Lactate, the end-product of glycolysis, is both metabolite and a signaling molecule. Moreover, studies have shown that lactic acid serves as both an energy source for tumor tissues and mediates histone lysine lactation as a modification substrate. Protein lactate modification has been shown to play a role in inflammation, neurodevelopment, and the occurrence and development of tumors
HostingRepository	PRIDE
AnnounceDate	2025-04-07
AnnouncementXML	Submission_2025-04-07_01:49:46.621.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xianliang Ma
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-13 14:36:17	ID requested
⏵ 1	2025-04-07 01:49:47	announced

Publication List

Hong H, Chen X, Wang H, Gu X, Yuan Y, Zhang Z, Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma. Proteomics, 23(9):e2200432(2023) [pubmed]
10.1002/pmic.202200432;

Hong H, Chen X, Wang H, Gu X, Yuan Y, Zhang Z, Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma. Proteomics, 23(9):e2200432(2023) [pubmed]

10.1002/pmic.202200432;

Keyword List

submitter keyword: lysine lactylation
HCC
post-translational modification
biological process
protein modification omics

submitter keyword: lysine lactylation

HCC

post-translational modification

biological process

protein modification omics

Contact List

Yin Yuan
contact affiliation	Department of Hepatobiliary Surgery of the affiliated Taizhou People's Hospital of Nanjing Medical University, 225300 Taizhou, Jiangsu Province, China
contact email	61736144@qq.com
lab head
Xianliang Ma
contact affiliation	Micrometer Biotech
contact email	maxianliangyxz@163.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD037371
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD037371

PRIDE project URI

Repository Record List

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