PXD037361

PXD037361 is an original dataset announced via ProteomeXchange.

Title	Hippocampus Proteomics analysis of 5×FAD::Alb-CreERT2;Ephx2−/− mice and control littermates (5×FAD::Ephx2loxp/loxp); Note: Hepatic Ephx2 deletion in 5×FAD::Alb-CreERT2;Ephx2−/− mice
Description	Alzheimer’s disease (AD) is the leading cause of late onset dementia. However, to date, no efficient therapy for AD is available. Here, we identified a neuroprotective role of the liver contributing to brain amyloid-β (Aβ) homeostasis. The hippocampus is a crucial region for learning and memory and is one of the brain areas most affected by AD. To investigate brain mechanisms underlying the neuroprotective role of the liver in AD pathology, we performed proteomics analysis of hippocampus extracted from 5×FAD::Alb-CreERT2;Ephx2−/− mice and control littermates. After quality control, we identified 67 protein expressions that were differently regulated between the two genotypes, including nine proteins in the Kyoto Encyclopedia of Genes and Genomes pathway of AD
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:49:32.585.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	yu wu
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-13 06:50:44	ID requested
1	2023-06-22 01:54:11	announced
2	2023-11-14 06:45:27	announced	2023-11-14: Updated project metadata.
⏵ 3	2024-10-22 05:49:32	announced	2024-10-22: Updated project metadata.

10.1016/J.NEURON.2023.06.002;

submitter keyword: 15-epoxyeicosatrienoic acid

Astrocytes

Apolipoprotein E,Liver

Soluble epoxide hydrolases

Alzheimer’s disease

14

Xinhong Zhu
contact affiliation	School of Psychology, Shenzhen University; Shenzhen 518060, China. Research Center for Brain Health, Pazhou Lab; Guangzhou, 510330, China.
contact email	zhuxh527@126.com
lab head
yu wu
contact affiliation	School of Psychology, Shenzhen University
contact email	wuyu923956656@126.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/06/PXD037361

PRIDE project URI

• PRIDE
  1. PXD037361
     1. Label: PRIDE project
     2. Name: Hippocampus Proteomics analysis of 5×FAD::Alb-CreERT2;Ephx2−/− mice and control littermates (5×FAD::Ephx2loxp/loxp); Note: Hepatic Ephx2 deletion in 5×FAD::Alb-CreERT2;Ephx2−/− mice