PXD037355 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | The structural dynamics of EGFR exon 19 mutants |
Description | Tyrosine kinase inhibitors (TKIs) are used to treat non-small cell lung cancers (NSCLC) driven by epidermal growth factor receptor (EGFR) mutations in the tyrosine kinase domain (TKD). TKI responses vary across tumors driven by the heterogeneous group of exon 19 deletions and mutations, but the molecular basis for these differences is not understood. We characterized the dynamics of the selected EGFR exon 19 mutants by HDX-MS to study the molecular basis of TKI sensitivity and tolerance. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:41:19.697.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yuko Tsutsui |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Synapt MS |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-10-13 02:14:42 | ID requested | |
1 | 2023-03-11 03:06:43 | announced | |
⏵ 2 | 2023-11-14 08:41:20 | announced | 2023-11-14: Updated project metadata. |
Publication List
van Alderwerelt van Rosenburgh IK, Lu DM, Grant MJ, Stayrook SE, Phadke M, Walther Z, Goldberg SB, Politi K, Lemmon MA, Ashtekar KD, Tsutsui Y, Biochemical and structural basis for differential inhibitor sensitivity of EGFR with distinct exon 19 mutations. Nat Commun, 13(1):6791(2022) [pubmed] |
Keyword List
submitter keyword: Exon 19,HDX-MS, EGFR |
Contact List
Yuko Tsutsui |
contact affiliation | Yale Cancer Biology Institute |
contact email | yuko.tsutsui@yale.edu |
lab head | |
Yuko Tsutsui |
contact affiliation | Yale Cancer Biology Institute |
contact email | yuko.tsutsui@yale.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD037355 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD037355
- Label: PRIDE project
- Name: The structural dynamics of EGFR exon 19 mutants