PXD037353

PXD037353 is an original dataset announced via ProteomeXchange.

Title	BCAA insufficiencies lead to premature ovarian insufficiency via ceramide induced elevation of ROS
Description	Premature ovarian insufficiency (POI) is a disease featured by early menopause before 40 years of age, accompanied by an elevation of follicle-stimulating hormone (FSH). Though POI affects many aspects of women’s health, its major causes remain unknown. Many clinical studies have shown that POI patients are generally underweight, indicating a potential correlation between POI and metabolic disorders. To understand the pathogenesis of POI, we performed metabolomics analysis on serum and identified branch chain amino acid (BCAA) insufficiency related metabolic disorders in two independent cohorts from two clinics. A low BCAA diet phenotypically reproduced the metabolic, endocrine, ovarian, and reproductive changes of POI in young C57 B6 mice. A mechanism study revealed that the BCAA insufficiency induced POI is associated with abnormal activation of the ceramide-ROS axis and consequent impairment of ovarian granulosa cell function. Significantly, dietary supplement of BCAA prevented the development of ROS-induced POI in female mice. The results of this pathogenic study will lead to the development of specific therapies for POI.
HostingRepository	iProX
AnnounceDate	2022-10-13
AnnouncementXML	Submission_2023-04-18_19:23:03.241.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xiao Guo
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-13 00:54:37	ID requested
1	2022-10-13 00:55:04	announced
⏵ 2	2023-04-18 19:23:04	announced	2023-04-19: Update publication information.

Guo X, Zhu Y, Guo L, Qi Y, Liu X, Wang J, Zhang J, Cui L, Shi Y, Wang Q, Liu C, Lu G, Liu Y, Li T, Hong S, Qin Y, Xiong X, Wu H, Huang L, Huang H, Gu C, Li B, Li J, BCAA insufficiency leads to premature ovarian insufficiency via ceramide-induced elevation of ROS. EMBO Mol Med, 15(4):e17450(2023) [pubmed]

submitter keyword: Low BCAA diet, Premature ovarian insufficiency, Ceramide, ROS

Jin Li
contact affiliation	Fudan University
contact email	li_jin_lifescience@fudan.edu.cn
lab head
Xiao Guo
contact affiliation	Fudan University
contact email	19210700052@fudan.edu.cn
dataset submitter

iProX dataset URI