PXD037325

PXD037325 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Phosphoproteomic analysis of ADNP-mutant mice
Description	We report age-differential synaptic plasticity deficits associated with cognitive inflexibility and CaMKIIa hyperactivity in Adnp-mutant mice. These mice show impaired and inflexible contextual learning and memory along with social and anxiety-related deficits in adults, long after the juvenile-stage decrease of ADNP protein levels to ~10% of the newborn level. Adnp-mutant mice show abnormally enhanced long-term potentiation in adults but not in juveniles. This is accompanied by CaMKIIa hyperactivity involving increased baseline autophosphorylation and altered phosphorylation of CaMKIIa substrates, as revealed by unbiased proteomic analyses.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:53:24.207.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yeji Yang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-12 08:31:57	ID requested
1	2023-07-11 01:42:16	announced
2	2023-11-14 07:07:26	announced	2023-11-14: Updated project metadata.
⏵ 3	2024-10-22 05:53:24	announced	2024-10-22: Updated project metadata.

Publication List

10.1038/S41380-023-02129-5;

10.1038/S41380-023-02129-5;

Keyword List

submitter keyword: Phosphoproteomics, Autism spectrum disorder,ADNP Syndrome, LC-MS/MS

submitter keyword: Phosphoproteomics, Autism spectrum disorder,ADNP Syndrome, LC-MS/MS

Contact List

Eunjoon Kim
contact affiliation	Department of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST), Daejeon 34141, Korea
contact email	eunjoonkim1@gmail.com
lab head
Yeji Yang
contact affiliation	Korea Basic Science Institute
contact email	yangyj@kbsi.re.kr
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD037325
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD037325

PRIDE project URI

Repository Record List

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