PXD037317

PXD037317 is an original dataset announced via ProteomeXchange.

Title	Breast cancer cell MCF7+CYP1B1-AS1 LC-MS/MS
Description	Long non-coding Rnas (lncRNAs) can act as oncogenes or tumor suppressors to regulate cancer development. We found that CYP1B1-AS1 was down-regulated in breast cancer tissues and correlated with the prognosis of patients. Lentiviral vectors were used to overexpress CYP1B1-AS1 in MCF7 cells, and the target proteins bound to CYP1B1-AS1 were detected by pulldown assay and mass spectrometry. The function of CYP1B1-AS1 is unknown. Our study revealed the molecular mechanism of CYP1B1-AS1 inhibiting breast cancer proliferation in breast cancer, and provided a new strategy for the treatment of breast cancer targeting lncRNA.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:06:44.673.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	li tang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-12 08:31:16	ID requested
1	2023-10-24 10:52:21	announced
⏵ 2	2023-11-14 09:06:52	announced	2023-11-14: Updated project metadata.

Tang L, Wei D, Xu X, Mo D, Cheng D, Yan F, FOXO1-regulated lncRNA CYP1B1-AS1 suppresses breast cancer cell proliferation by inhibiting neddylation. Breast Cancer Res Treat, 202(2):397-408(2023) [pubmed]

submitter keyword: CYP1B1-AS1,MCF7

Feng Yan
contact affiliation	Department of Clinical Laboratory, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, China.
contact email	yanfeng@jszlyy.com.cn
lab head
li tang
contact affiliation	Jiangsu Cancer Hospital
contact email	tangyinhome@126.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD037317

PRIDE project URI

• PRIDE
  1. PXD037317
     1. Label: PRIDE project
     2. Name: Breast cancer cell MCF7+CYP1B1-AS1 LC-MS/MS