PXD037301

PXD037301 is an original dataset announced via ProteomeXchange.

Title	Stellettin B renders glioblastoma vulnerable to poly (ADP-ribose) polymerase inhibitors via suppressing homology-directed repair
Description	Glioblastoma (GBM) is the most malignant tumor of the central nervous system. Current first-line post-surgery regimens for GBM including radiotherapy and temozolomide (TMZ) chemotherapy show very limited efficacy, with a median overall survival of only 15 months. Therefore, the development of therapeutic strategies and novel agents for GBM patients is an urgent need. Historically, natural products have played a key role in drug discovery, especially in the field of cancer treatment. We previously isolated stellettin B (STELB), an isomalabaricane triterpenoid, from marine sponge Jaspis stellifera and reported its remarkable and specific anticancer activities, which has attracted wide attention. Recently, a series of stellettins has been totally synthesized, removing a major barrier in drug development for the whole family of these chemicals. Notably, previous structure-activity relationship (SAR) studies have shown that stellettin A, B, and E share a singular trans-syn-trans perhydrobenz[e]indene core that is indispensable for their anticancer effects. However, the specific mechanism and its role in regulating tumor biology remain largely unknown.
HostingRepository	iProX
AnnounceDate	2022-10-11
AnnouncementXML	Submission_2023-09-11_20:54:24.219.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xin Peng
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-11 20:11:29	ID requested
⏵ 1	2023-09-11 20:54:26	announced

Peng X, Wang Y, Zhang S, Tao Z, Dai Y, Claret FX, Elkabets M, Lin HW, Chen ZS, Kong D, Stellettin B renders glioblastoma vulnerable to poly (ADP-ribose) polymerase inhibitors via suppressing homology-directed repair. Signal Transduct Target Ther, 8(1):119(2023) [pubmed]

submitter keyword: Stellettin B, glioblastoma, PARP inhibitor

Dexin Kong
contact affiliation	Tianjin Medical University
contact email	kongdexin@tmu.edu.cn
lab head
Xin Peng
contact affiliation	Tianjin Medical University
contact email	pengxin@tmu.edu.cn
dataset submitter

iProX dataset URI