PXD037247

PXD037247 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	LC-MS/MS analysis of human brain fibroblast-secreted molecules
Description	Our study showed that fibroblasts significantly attenuated blood-brain barrier (BBB) disruption in an in vitro intracerebral hemorrhage (ICH) model. Since fibroblasts and brain microvascular endothelial cells were not in direct contact in this model, we reasoned that fibroblasts did so by secreting molecules with BBB-protective function. Here, we further screened fibroblast-secreted molecules in this in vitro ICH model by mass spectrometry.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:32:18.372.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD037247
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Yao Yao
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Elite

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-10 07:34:53	ID requested
1	2022-11-14 03:31:29	announced
⏵ 2	2023-11-14 08:32:19	announced	2023-11-14: Updated project metadata.

Publication List

10.6019/PXD037247;
Xu L, Nirwane A, Xu T, Kang M, Devasani K, Yao Y, Fibroblasts repair blood-brain barrier damage and hemorrhagic brain injury via TIMP2. Cell Rep, 41(8):111709(2022) [pubmed]

10.6019/PXD037247;

Xu L, Nirwane A, Xu T, Kang M, Devasani K, Yao Y, Fibroblasts repair blood-brain barrier damage and hemorrhagic brain injury via TIMP2. Cell Rep, 41(8):111709(2022) [pubmed]

Keyword List

submitter keyword: Human, LC-MSMS, Brain fibroblasts

submitter keyword: Human, LC-MSMS, Brain fibroblasts

Contact List

Yao Yao
contact affiliation	University of South Florida, Morsani College of Medicine, Department of Molecular Pharmacology and Physiology
contact email	yao7@usf.edu
lab head
Yao Yao
contact affiliation	University of South Florida
contact email	yao7@usf.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/11/PXD037247
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/11/PXD037247

PRIDE project URI

Repository Record List

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