PXD037235

PXD037235 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	LFQ proteomics analysis of M. smegmatis treated with BacPROTACs.
Description	To monitor selective degradation of ClpC1 and ClpC2 using BacPROTAC compounds in M. smegmatis we performed a LFQ proteomics analysis treating the cells at bactericidal compound concentration. We detected degradation of both proteins and additional dysregulation of the mycobacterial PQC system.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:47:00.108.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	David Hoi
SpeciesList	scientific name: Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155); NCBI TaxID: 246196;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-10 07:19:37	ID requested
1	2023-06-07 01:28:00	announced
2	2023-11-14 08:59:05	announced	2023-11-14: Updated project metadata.
⏵ 3	2024-10-22 05:47:00	announced	2024-10-22: Updated project metadata.

Publication List

10.1016/J.CELL.2023.04.009;

10.1016/J.CELL.2023.04.009;

Keyword List

submitter keyword: antibiotics, TPD, BacPROTAC, PROTAC,protein degradation

submitter keyword: antibiotics, TPD, BacPROTAC, PROTAC,protein degradation

Contact List

Markus Hartl
contact affiliation	Max Perutz Labs, Vienna, Austria
contact email	markus.hartl@univie.ac.at
lab head
David Hoi
contact affiliation	IMP
contact email	david.hoi@imp.ac.at
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/06/PXD037235
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/06/PXD037235

PRIDE project URI

Repository Record List

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