PXD037234 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | LFQ proteomics analysis of M. smegmatis treated with CymA and ecumicin (Part 2). |
Description | To assess the impact of the bactericidal compounds CymA and ecumicin on the mycobacterial proteome and to monitor proteome remodeling by the AAA+ ClpC1 protease machinery, we performed a LFQ proteomics analysis treating the cells at bactericidal compound concentration. We identified new players of the mycobacterial ClpC1 stress response (ClpC2 and ClpC3), as novel bacterial antibiotic resistance mechanism. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:59:05.299.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | David Hoi |
SpeciesList | scientific name: Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155); NCBI TaxID: 246196; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-10-10 07:17:57 | ID requested | |
1 | 2023-06-07 01:56:00 | announced | |
⏵ 2 | 2023-11-14 08:59:05 | announced | 2023-11-14: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: antibiotics, tuberculosis,TPD, protein degradation |
Contact List
Markus Hartl |
contact affiliation | Max Perutz Labs, Vienna, Austria |
contact email | markus.hartl@univie.ac.at |
lab head | |
David Hoi |
contact affiliation | IMP |
contact email | david.hoi@imp.ac.at |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD037234
- Label: PRIDE project
- Name: LFQ proteomics analysis of M. smegmatis treated with CymA and ecumicin (Part 2).