PXD037229

PXD037229 is an original dataset announced via ProteomeXchange.

Title	Human brain glycoproteomic network alterations in Alzheimer’s disease
Description	We performed a large-scale, site-specific N-glycoproteome profiling study of human Alzheimer’s disease (AD) and control brains using mass spectrometry–based quantitative N-glycoproteomics. The study provided a system-level view of human brain N-glycoproteins and in vivo N-glycosylation sites and identified disease signatures of altered N-glycopeptides, N-glycoproteins, and N-glycosylation site occupancy in AD. Glycoproteomic data-driven network analysis showed 13 modules of co-regulated N-glycopeptides/glycoproteins, 6 of which are associated with AD phenotypes.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:27:21.671.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	QI ZHANG
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; (18)O labeled deglycosylated asparagine; deamidated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-10 07:05:25	ID requested
1	2022-11-01 20:40:56	announced
⏵ 2	2023-11-14 08:27:24	announced	2023-11-14: Updated project metadata.

Zhang Q, Ma C, Chin LS, Li L, Integrative glycoproteomics reveals protein N-glycosylation aberrations and glycoproteomic network alterations in Alzheimer's disease. Sci Adv, 6(40):(2020) [pubmed]

submitter keyword: mass spectrometry, glycoproteomics,Alzheimer's disease

Lian Li
contact affiliation	Department of Pharmacology and Chemical Biology Emory University
contact email	lli5@emory.edu
lab head
QI ZHANG
contact affiliation	Emory University
contact email	QZHAN50@emory.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/11/PXD037229

PRIDE project URI

• PRIDE
  1. PXD037229
     1. Label: PRIDE project
     2. Name: Human brain glycoproteomic network alterations in Alzheimer’s disease