PXD037189

PXD037189 is an original dataset announced via ProteomeXchange.

Title	PITX2 defiency identifies changes in sarcomere structure and mitochondrial dysfunktion as substrates for atrial fibrillation
Description	Atrial fibrillation affects 2-3% of the population and is associated with high morbidity and mortality from cardiovascular causes in patients. Common gene variants on chromosome 4q25 show the strongest genomic disease association and reside in an enhancer region regulating the Paired like Homeodomain 2 (PITX2) gene. Mechanisms how PITX2 is linked with AF remains unknown. Differences in protein abundance was compared in PITX2 knockout human induced pluripotent stem cell-derived atrial cardiomyocytes and their respective isogenic controls from six independent differentiation runs.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_09:23:34.238.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sönke Harder
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-05 00:56:10	ID requested
⏵ 1	2025-05-06 09:23:35	announced

10.1093/cvr/cvae169;

Reyat JS, Sommerfeld LC, O'Reilly M, Roth Cardoso V, Thiemann E, Khan AO, O'Shea C, Harder S, M, ü, ller C, Barlow J, Stapley RJ, Chua W, Kabir SN, Grech O, Hummel O, H, ü, bner N, K, ä, ä, b S, Mont L, Hatem SN, Winters J, Zeemering S, Morgan NV, Rayes J, Gehmlich K, Stoll M, Brand T, Schweizer M, Piasecki A, Schotten U, Gkoutos GV, Lorenz K, Cuello F, Kirchhof P, Fabritz L, PITX2 deficiency leads to atrial mitochondrial dysfunction. Cardiovasc Res, 120(15):1907-1923(2024) [pubmed]

submitter keyword: cardiomyocytes,stem cell, PITX" knockout

Fiederike Cuello
contact affiliation	Institut für Experimentelle Pharmakologie und Toxikologie
contact email	f.cuello@uke.de
lab head
Sönke Harder
contact affiliation	University of Hamburg ,Institut für Klinische Chemie und Laboratoriumsmedizin Zentrum für Diagnostik Massenspektrometrische Proteomanalytik
contact email	harder@uke.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD037189

PRIDE project URI

• PRIDE
  1. PXD037189
     1. Label: PRIDE project
     2. Name: PITX2 defiency identifies changes in sarcomere structure and mitochondrial dysfunktion as substrates for atrial fibrillation