PXD037163

PXD037163 is an original dataset announced via ProteomeXchange.

Title	Yangyinqingfei Decoction attenuates PM2.5-induced lung injury by enhancing arachidonic acid metabolism
Description	Yangyinqingfei Decoction (YYQFD), a traditional Chinese prescription, is well known in the treatment of diphtheria and lung-related diseases in clinic. However, the underlying mechanism how to treat lung-related diseases remains unclear. In the present study, the intervention effect of YYQFD on PM2.5-induced lung injury mice and its potential mechanism were investigated by metabolomics and proteomic techniques. The results showed that YYQFD could significantly improve pulmonary functions, relieve lung injury, as well as reduce IL-6, TNF-α and MDA, and increase SOD levels in serum and BALF of PM2.5-induced lung injury mice. Furthermore, the protein-metabolite joint analysis presented that YYQFD regulated the pathways of arachidonic acid metabolism, linoleic acid metabolism, and biosynthesis of unsaturated fatty acids with significantly down-regulating arachidonic acid, 20-HETE, prostaglandin E2, lecithin, linoleic acid, α-linolenic acid, eicosatetraenoic acid, and γ-linolenic acid, and up-regulating PTGES2, GPX2 and CBR3 protein expressions in lung tissue. A regulatory metabolic network map was further constructed, which provide us a better understanding about the role of YYQFD on PM2.5-induced lung injury mice and new insight into YYQFD application for the treatment of lung-related diseases.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:58:20.814.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chunlan Tang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-03 11:27:41	ID requested
1	2022-12-21 21:38:26	announced
⏵ 2	2023-11-14 08:58:21	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: Metabolomics,Yangyinqingfei Decoction, Arachidonic acid metabolism, Lung injury, Proteomics

Chunlan Tang
contact affiliation	Ningbo University
contact email	chunlant@163.com
lab head
Chunlan Tang
contact affiliation	School of Medicine, Ningbo University
contact email	chunlant@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/12/PXD037163

PRIDE project URI

• PRIDE
  1. PXD037163
     1. Label: PRIDE project
     2. Name: Yangyinqingfei Decoction attenuates PM2.5-induced lung injury by enhancing arachidonic acid metabolism