PXD037122 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Interactome of Sec13 paralogs in Paradiplonema papillatum |
| Description | The acquisition of new functions is frequently the result of gene duplication and is a major driver of evolutionary complexity. The β-propeller protein Sec13 plays roles in at least three distinct processes by virtue of being a component of the COPII endoplasmic reticulum export vesicle coat, the nuclear pore complex (NPC) and the Seh1-associated (SEA)/GATOR nutrient-sensing complex, suggesting that regulatory mechanisms coordinating these cellular activities may operate via Sec13. COPII, SEA and the NPC are ancient features of eukaryotic cells. We analyzed the Sec13 interactome in diplonemids, widespread marine protists, and found that Sec13 functions are divided between two paralogs, Sec13a and Sec13b. Sec13a interacts with COPII and the NPC, but by contrast Sec13b interacts with Sec16 and components of the SEA/GATOR complex. Hence, we infer that Sec13a is responsible for NPC functions and canonical anterograde transport activities while Sec13b acts within nutrient and autophagy-related pathways. Furthermore, duplication of Sec13 is near universal across the Euglenozoa, providing a potent exemplar of paralogy expansion and functional diversification. |
| HostingRepository | PRIDE |
| AnnounceDate | 2024-10-22 |
| AnnouncementXML | Submission_2024-10-22_05:48:07.797.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Corinna Benz |
| SpeciesList | scientific name: Diplonema papillatum; NCBI TaxID: 91374; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2022-09-30 04:38:02 | ID requested | |
| 1 | 2023-06-13 23:29:18 | announced | |
| 2 | 2023-11-14 09:00:55 | announced | 2023-11-14: Updated project metadata. |
| ⏵ 3 | 2024-10-22 05:48:08 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
| submitter keyword: paralog expansion,Diplonema |
| coatomer |
| membrane-trafficking |
| Sec13 |
| nuclear pore complex (NPC) |
| SEA/GATOR complex, evolutionary mechanisms |
Contact List
| Julius Lukes |
|---|
| contact affiliation | Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice (Budweis), Czech Republic; Faculty of Sciences, University of South Bohemia, České Budějovice (Budweis), Czech Republic |
| contact email | jula@paru.cas.cz |
| lab head | |
| Corinna Benz |
|---|
| contact affiliation | Institute of Parasitology Biology Center, Czech Academy of Sciences Branišovská 31 370 05 České Budějovice |
| contact email | corinna.benz@paru.cas.cz |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/06/PXD037122 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD037122
- Label: PRIDE project
- Name: Interactome of Sec13 paralogs in Paradiplonema papillatum
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