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PXD037122

PXD037122 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleInteractome of Sec13 paralogs in Paradiplonema papillatum
DescriptionThe acquisition of new functions is frequently the result of gene duplication and is a major driver of evolutionary complexity. The β-propeller protein Sec13 plays roles in at least three distinct processes by virtue of being a component of the COPII endoplasmic reticulum export vesicle coat, the nuclear pore complex (NPC) and the Seh1-associated (SEA)/GATOR nutrient-sensing complex, suggesting that regulatory mechanisms coordinating these cellular activities may operate via Sec13. COPII, SEA and the NPC are ancient features of eukaryotic cells. We analyzed the Sec13 interactome in diplonemids, widespread marine protists, and found that Sec13 functions are divided between two paralogs, Sec13a and Sec13b. Sec13a interacts with COPII and the NPC, but by contrast Sec13b interacts with Sec16 and components of the SEA/GATOR complex. Hence, we infer that Sec13a is responsible for NPC functions and canonical anterograde transport activities while Sec13b acts within nutrient and autophagy-related pathways. Furthermore, duplication of Sec13 is near universal across the Euglenozoa, providing a potent exemplar of paralogy expansion and functional diversification.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:48:07.797.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterCorinna Benz
SpeciesList scientific name: Diplonema papillatum; NCBI TaxID: 91374;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-09-30 04:38:02ID requested
12023-06-13 23:29:18announced
22023-11-14 09:00:55announced2023-11-14: Updated project metadata.
32024-10-22 05:48:08announced2024-10-22: Updated project metadata.
Publication List
10.1098/RSOB.220364;
Keyword List
submitter keyword: paralog expansion,Diplonema
coatomer
membrane-trafficking
Sec13
nuclear pore complex (NPC)
SEA/GATOR complex, evolutionary mechanisms
Contact List
Julius Lukes
contact affiliationInstitute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice (Budweis), Czech Republic; Faculty of Sciences, University of South Bohemia, České Budějovice (Budweis), Czech Republic
contact emailjula@paru.cas.cz
lab head
Corinna Benz
contact affiliationInstitute of Parasitology Biology Center, Czech Academy of Sciences Branišovská 31 370 05 České Budějovice
contact emailcorinna.benz@paru.cas.cz
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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