Update publication information. Update publication information. The Yiqi Sanjie (YQSJ) formula has been proved to be clinically useful for stage III colorectal cancer (CRC) patients. However, the exact anti-tumor mechanisms of YQSJ and its main active component peiminine remain incompletely understood. This study aimed to comprehensively explore the characterization of CRC tissues/cells and gut microbes mediated by YQSJ/peiminine through integrative analyses.