PXD037093

PXD037093 is an original dataset announced via ProteomeXchange.

Title	Isolation and Characterization of ZK002, A Novel Dual Function Snake Venom Peptide from Deinagkistrodon acutus with Anti-angiogenic and Anti-inflammatory Properties
Description	Pathological angiogenesis, the abnormal or excessive generation of blood vessels, plays an important role in many diseases including cancer, diabetic retinopathy, psoriasis, and arthritis. Additionally, increasing evidence supports the close linkage between angiogenesis and inflammation. Snake venoms are a rich natural source of biologically active molecules and carry rich potential for the discovery anti-angiogenic and anti-inflammatory modulators. Here, we isolated and purified a novel protein, ZK002, from the venom of the snake Deinagkistrodon acutus, and investigated its anti-angiogenic and anti-inflammatory activities and mechanisms.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:06:41.277.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD037093
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	William Chi-Shing Tai
SpeciesList	scientific name: Deinagkistrodon acutus; NCBI TaxID: 36307;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2022-09-30 03:47:30	ID requested
1	2023-10-24 10:50:34	announced
⏵ 2	2023-11-14 09:06:43	announced	2023-11-14: Updated project metadata.

10.6019/PXD037093;

Chan BD, Wong WY, Lee MM, Yue PY, Dai X, Tsim KW, Hsiao WW, Li M, Li XY, Tai WC, with anti-angiogenic and anti-inflammatory properties. Front Pharmacol, 14():1227962(2023) [pubmed]

submitter keyword: ZK002

snake venom

anti-angiogenesis

anti-inflammation

William Chi-Shing Tai
contact affiliation	Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hung Hom, Hong Kong S.A.R., China
contact email	william-cs.tai@polyu.edu.hk
lab head
William Chi-Shing Tai
contact affiliation	The Hong Kong Polytechnic University
contact email	william-cs.tai@polyu.edu.hk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD037093

PRIDE project URI

• PRIDE
  1. PXD037093
     1. Label: PRIDE project
     2. Name: Isolation and Characterization of ZK002, A Novel Dual Function Snake Venom Peptide from Deinagkistrodon acutus with Anti-angiogenic and Anti-inflammatory Properties