PXD037052

PXD037052 is an original dataset announced via ProteomeXchange.

Title	Sutureless repair of large-diameter corneal defects using natural polymer-derived photocurable bioadhesive hydrogels
Description	The in situ formation of adhesive hydrogels can repair of corneal defects but most focused on repairing focal stromal defects with diameters ≤ 3.5 mm because of their weak adhesion to wet tissues and fast biodegradation rate. Herein, a photocurable bioadhesive hydrogel that mimics the extracellular matrix (ECM) composition is developed for repairing 6-mm-diameter corneal stromal defects in rabbits. This biomacromolecule-based matrix hydrogel can undergo rapid gelling after UV light irradiation, exhibiting a high light transmittance and favorable mechanics. More importantly, this hydrogel maintained the viability and adhesion of cornea-derived cells and promoted their migration in vitro in 2D and 3D culture environments. Furthermore, in a rabbit corneal stromal defect model, the bioadhesive hydrogel could rapidly sealed wet corneal defects, resulting in epithelial wound coverage within 3-4 weeks, thereby contributing to a decrease in scar formation and increase in corneal stromal-neural regeneration during the 6-month follow-up. Thus, this work indicates that the biomacromolecule-based matrix hydrogel displays great potential for the regeneration of large-diameter corneal defects.
HostingRepository	iProX
AnnounceDate	2022-09-28
AnnouncementXML	Submission_2022-09-27_20:38:12.084.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Fuyan Wang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606; scientific name: Oryctolagus cuniculus; NCBI TaxID: 9986;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2022-09-27 20:37:53	ID requested
⏵ 1	2022-09-27 20:38:12	announced

Dataset with its publication pending

submitter keyword: Large-diameter corneal defect, Bioadhesive hydrogel, Extracellular matrix, Corneal regeneration

Qingjun Zhou
contact affiliation	Eye Institute of Shandong First Medical University
contact email	qjzhou2000@hotmail.com
lab head
Fuyan Wang
contact affiliation	Eye Institute of Shandong First Medical University
contact email	taiyixueqi@163.com
dataset submitter

iProX dataset URI