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PXD037052

PXD037052 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSutureless repair of large-diameter corneal defects using natural polymer-derived photocurable bioadhesive hydrogels
DescriptionThe in situ formation of adhesive hydrogels can repair of corneal defects but most focused on repairing focal stromal defects with diameters ≤ 3.5 mm because of their weak adhesion to wet tissues and fast biodegradation rate. Herein, a photocurable bioadhesive hydrogel that mimics the extracellular matrix (ECM) composition is developed for repairing 6-mm-diameter corneal stromal defects in rabbits. This biomacromolecule-based matrix hydrogel can undergo rapid gelling after UV light irradiation, exhibiting a high light transmittance and favorable mechanics. More importantly, this hydrogel maintained the viability and adhesion of cornea-derived cells and promoted their migration in vitro in 2D and 3D culture environments. Furthermore, in a rabbit corneal stromal defect model, the bioadhesive hydrogel could rapidly sealed wet corneal defects, resulting in epithelial wound coverage within 3-4 weeks, thereby contributing to a decrease in scar formation and increase in corneal stromal-neural regeneration during the 6-month follow-up. Thus, this work indicates that the biomacromolecule-based matrix hydrogel displays great potential for the regeneration of large-diameter corneal defects.
HostingRepositoryiProX
AnnounceDate2022-09-28
AnnouncementXMLSubmission_2022-09-27_20:38:12.084.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterFuyan Wang
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606; scientific name: Oryctolagus cuniculus; NCBI TaxID: 9986;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-09-27 20:37:53ID requested
12022-09-27 20:38:12announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Large-diameter corneal defect, Bioadhesive hydrogel, Extracellular matrix, Corneal regeneration
Contact List
Qingjun Zhou
contact affiliationEye Institute of Shandong First Medical University
contact emailqjzhou2000@hotmail.com
lab head
Fuyan Wang
contact affiliationEye Institute of Shandong First Medical University
contact emailtaiyixueqi@163.com
dataset submitter
Full Dataset Link List
iProX dataset URI