PXD037052
PXD037052 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Sutureless repair of large-diameter corneal defects using natural polymer-derived photocurable bioadhesive hydrogels |
Description | The in situ formation of adhesive hydrogels can repair of corneal defects but most focused on repairing focal stromal defects with diameters ≤ 3.5 mm because of their weak adhesion to wet tissues and fast biodegradation rate. Herein, a photocurable bioadhesive hydrogel that mimics the extracellular matrix (ECM) composition is developed for repairing 6-mm-diameter corneal stromal defects in rabbits. This biomacromolecule-based matrix hydrogel can undergo rapid gelling after UV light irradiation, exhibiting a high light transmittance and favorable mechanics. More importantly, this hydrogel maintained the viability and adhesion of cornea-derived cells and promoted their migration in vitro in 2D and 3D culture environments. Furthermore, in a rabbit corneal stromal defect model, the bioadhesive hydrogel could rapidly sealed wet corneal defects, resulting in epithelial wound coverage within 3-4 weeks, thereby contributing to a decrease in scar formation and increase in corneal stromal-neural regeneration during the 6-month follow-up. Thus, this work indicates that the biomacromolecule-based matrix hydrogel displays great potential for the regeneration of large-diameter corneal defects. |
HostingRepository | iProX |
AnnounceDate | 2022-09-28 |
AnnouncementXML | Submission_2022-09-27_20:38:12.084.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Fuyan Wang |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; scientific name: Oryctolagus cuniculus; NCBI TaxID: 9986; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2022-09-27 20:37:53 | ID requested | |
⏵ 1 | 2022-09-27 20:38:12 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Large-diameter corneal defect, Bioadhesive hydrogel, Extracellular matrix, Corneal regeneration |
Contact List
Qingjun Zhou | |
---|---|
contact affiliation | Eye Institute of Shandong First Medical University |
contact email | qjzhou2000@hotmail.com |
lab head | |
Fuyan Wang | |
contact affiliation | Eye Institute of Shandong First Medical University |
contact email | taiyixueqi@163.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |