PXD037026

PXD037026 is an original dataset announced via ProteomeXchange.

Title	Identification of mono-ADPr readers by multilevel chromatin proteomics
Description	We performed multilevel proteomics to identify mono-ADPr readers. Pulldowns using ADPribosylated peptides and nucleosomes, analysis of the chromatin proteome using targeted modulations of the ADPr system (H2O2 treatment, ARH3 KO, HPF1 KO). We reveal multiple mono-ADPr readers, including RNF114, a ubiquitin ligase recruited to DNA lesions through a zinc finger domain.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:59:05.181.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Thomas Colby
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos; Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-09-27 11:20:24	ID requested
1	2023-04-28 05:32:35	announced
⏵ 2	2023-11-14 08:59:05	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: ADPribosylation, histone marks, human, PTM,Mono-ADPr, chromatin, LC-MS/MS

Ivan Matic
contact affiliation	Max Planck Institute for Biology of Ageing Cologne, Germany
contact email	imatic@age.mpg.de
lab head
Thomas Colby
contact affiliation	MPI for Biology of Ageing
contact email	colby@age.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/04/PXD037026

PRIDE project URI

• PRIDE
  1. PXD037026
     1. Label: PRIDE project
     2. Name: Identification of mono-ADPr readers by multilevel chromatin proteomics