PXD037000

PXD037000 is an original dataset announced via ProteomeXchange.

Title	Proteolytic processing of galectin-3 is crucial for host microbiome homeostasis
Description	To identify relevant substrates for meprin α/β heterodimers, we applied mass spectrometry-based N-terminomics of mouse colon tissue as well as of human Caco-2 cells and identified galectin-3 as a novel intestinal substrate. The proteolytic processing of galectin-3 by meprin α/β heterodimers plays a key role in the maintenance of the host-microbiome homeostasis within the colon.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:46:05.182.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Andreas Tholey
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF; Orbitrap Fusion Lumos; Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-09-25 15:24:03	ID requested
1	2023-05-10 09:55:26	announced
⏵ 2	2023-11-14 08:46:13	announced	2023-11-14: Updated project metadata.

B, ü, lck C, Nystr, ö, m EEL, Koudelka T, Mannbar-Frahm M, Andresen G, Radhouani M, Tran F, Scharfenberg F, Schrell F, Armbrust F, Dahlke E, Zhao B, Vervaeke A, Theilig F, Rosenstiel P, Starkl P, Rosshart SP, Fickenscher H, Tholey A, Hansson GC, Becker-Pauly C, Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host-microbiome homeostasis. Sci Adv, 9(13):eadf4055(2023) [pubmed]

submitter keyword: LC-MS,meprin, N-terminomics

Andreas Tholey
contact affiliation	Institute of Experimental Medicine, University of Kiel, 24188 Kiel, Germany
contact email	a.tholey@iem.uni-kiel.de
lab head
Andreas Tholey
contact affiliation	Systematic Proteome Research & Bioanalytics, University of Kiel
contact email	a.tholey@iem.uni-kiel.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/05/PXD037000

PRIDE project URI

• PRIDE
  1. PXD037000
     1. Label: PRIDE project
     2. Name: Proteolytic processing of galectin-3 is crucial for host microbiome homeostasis