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PXD036991

PXD036991 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleLabel-free quantitative proteomics of gastric high-grade intraepithelial neoplasia
DescriptionPurpose: Early detection and diagnosis are the keys to improving the survival rate and reducing the fatality rate linked to gastric cancer. The precancerous lesion of gastric cancer is referred to as Gastric high-grade intraepithelial neoplasia (HGIN). Both sensitivity and specificity of current biomarkers that aid in the diagnosis of gastric HGIN are still relatively low. The proteomic data of gastric HGIN are still scarce. The study aimed to explore candidate protein biomarkers for gastric HGIN screening with proteomics and bioinformatics technology. Methods: A total of 10 serum samples were collected and categorized into two groups, that is, the gastric HGIN and the healthy control groups. Label-free quantification (LFQ) in conjunction with liquid chromatography with tandem mass spectrometry (LC-MS/MS) was employed to identify the probable biomarkers for gastric HGIN. Further, differentially expressed proteins (DEPs) were quantified by the proteomic analysis. Results: In total, 1192 distinct serum proteins were discovered between the gastric HGIN group and the healthy control group. DEPs were recruited in the conduction of further analyses, utilizing a threshold of 1.5-fold difference in expression level (P < 0.05) in comparison with the control group. There were 18 upregulated and 12 downregulated proteins in the gastric HGIN group in contrast with the control group. Bioinformatics analyses were performed according to Gene Ontology (GO), cluster, and KEGG pathway enrichment analyses. Conclusions: Our data provide more biological information for the formation of gastric HGIN and provide clues for further research on the pathogenesis of early gastric cancer.
HostingRepositoryPRIDE
AnnounceDate2025-06-02
AnnouncementXMLSubmission_2025-06-01_16:08:09.977.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterNan Lin
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-09-25 14:57:57ID requested
12025-06-01 16:08:10announced
Publication List
Lin N, Lin L, Huang X, Huang C, Gong J, Label-free quantitative proteomics of gastric high-grade intraepithelial neoplasia. Exp Ther Med, 30(1):133(2025) [pubmed]
10.3892/etm.2025.12883;
Keyword List
submitter keyword: gastric cancer
gastric high-grade intraepithelial neoplasia
proteomics
label-free
Contact List
Nan Lin
contact affiliationThe Affiliated Hospital of Putian University
contact email642803499@qq.com
lab head
Nan Lin
contact affiliationthe Affiliated Hospital of Putian University
contact email642803499@qq.com
dataset submitter
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Dataset FTP location
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