PXD036901

PXD036901 is an original dataset announced via ProteomeXchange.

Title	Complexome profiling of brain mitochondria from WT and ClpP-/- mice
Description	Mutations in the gene for the mitochondrial matrix protease CLPP can cause human Perrault syndrome, which is characterized by male and female infertility, progressive sensorineural deafness, ataxia and leukoencephalopathy. This gene encodes a peptidase that is conserved since bacteria and localizes to mitochondrial matrix in eukaryotes. To assess the assembly and stability of mitochondrial complexes brain tissue of WT and ClpP-/- mice was dissected and enriched mitochondrial fraction was used for complexome profiling.
HostingRepository	PRIDE
AnnounceDate	2024-01-17
AnnouncementXML	Submission_2024-01-17_05:48:35.869.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jana Key
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-09-21 14:45:05	ID requested
⏵ 1	2024-01-17 05:48:36	announced

10.3390/IJMS242417503;

submitter keyword: Protease function, Complexome profiling

Georg Auburger
contact affiliation	Experimental Neurology, University Hospital, Frankfurt am Main, Germany
contact email	auburger@em.uni-frankfurt.de
lab head
Jana Key
contact affiliation	University Hospital Frankfurt am Main
contact email	jana.key88@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD036901

PRIDE project URI

• PRIDE
  1. PXD036901
     1. Label: PRIDE project
     2. Name: Complexome profiling of brain mitochondria from WT and ClpP-/- mice