PXD036881

PXD036881 is an original dataset announced via ProteomeXchange.

Title	Mycobacterium avium subsp. paratuberculosis infected cows reveal divergent immune response in bovine peripheral blood derived lymphocyte proteome
Description	Bovine paratuberculosis is a serious chronic disease of the gastrointestinal tract caused by Mycobacterium avium subspecies paratuberculosis (MAP). The aim of this study was to detect proteomic changes in peripheral blood mononuclear cells (PBMC) from cows of the same herd with different MAP infection status after co-incubation with viable MAP in vitro using label-free LC-MS/MS. Our data contribute to a better understanding of the bovine immune response and mechanisms of susceptibility to MAP.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:18:35.328.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Roxane Degroote
SpeciesList	scientific name: Bos taurus (Bovine); NCBI TaxID: 9913;
ModificationList	monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-09-21 00:59:03	ID requested
1	2023-03-10 13:43:18	announced
⏵ 2	2023-11-14 08:18:36	announced	2023-11-14: Updated project metadata.

Korbonits L, Kleinwort KJH, Amann B, Didier A, M, ä, rtlbauer E, Hauck SM, Deeg CA, Infected Cows Reveal Divergent Immune Response in Bovine Peripheral Blood Derived Lymphocyte Proteome. Metabolites, 12(10):(2022) [pubmed]

submitter keyword: paratuberculosis

mycobacteria

host-pathogen response

immune system

quantitative label-free LC-MS/MS

bovine

Stefanie M Hauck
contact affiliation	Research Unit Protein Science, Helmholtz Center Munich, German Research Center for Environmental Health GmbH, Germany
contact email	hauck@helmholtz-muenchen.de
lab head
Roxane Degroote
contact affiliation	LMU Munich, Veterinary Sciences, Chair of Physiology, Lena-Christ-Straße 48, 82152 Planegg/Martinsried, Germany
contact email	r.degroote@lmu.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD036881

PRIDE project URI

• PRIDE
  1. PXD036881
     1. Label: PRIDE project
     2. Name: Mycobacterium avium subsp. paratuberculosis infected cows reveal divergent immune response in bovine peripheral blood derived lymphocyte proteome