PXD036853

PXD036853 is an original dataset announced via ProteomeXchange.

Title	Global Analysis of Lysine Acetylation in the Brain Cortex of K18-hACE2 Mice Infected with SARS-CoV-2
Description	In order to research the relationship between neurological sequelae of COVID-19 and acetylation of brain cortexes, we reported for the first time the acetylome in the brain cortex of the K18-hACE2 infected mouse model, and the difference between the SARS-CoV-2 infection group and the control group, which found the largest amount of acetylated proteins in the brain cortex of the mouse to date, greatly expanding the existing database of acetylome. Besides, it would also lay a foundation for the subsequent research on the pathogenesis and treatment of COVID-19 patients.
HostingRepository	iProX
AnnounceDate	2022-09-20
AnnouncementXML	Submission_2024-03-20_00:11:45.153.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Qiaochu Wang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	acetylated residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2022-09-20 00:18:20	ID requested
⏵ 1	2024-03-20 00:11:46	announced

Wang Q, Peng W, Yang Y, Wu Y, Han R, Ding T, Zhang X, Liu J, Liu J, Yang J, Global analysis of lysine acetylation in the brain cortex of K18-hACE2 mice infected with SARS-CoV-2. Proteomics, 23(16):e2300096(2023) [pubmed]

submitter keyword: Brain cortex, Lysine acetylation, K18-hACE2, SARS-CoV-2

Juntao Yang
contact affiliation	Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences
contact email	yangjt@pumc.edu.cn
lab head
Qiaochu Wang
contact affiliation	Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences
contact email	wangqiaochu@ibms.pumc.edu.cn
dataset submitter

iProX dataset URI