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PXD036821

PXD036821 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe accessory protein ORF6 contributes to SARS-CoV-2 pathogenesis by regulating host and viral gene expression
DescriptionWe generated a SARS-CoV-2 virus in the Wuhan background with a deletion of the Orf6 gene. We then performed mass spectrometry abundance proteomics and phosphoproteomics analysis of infected cells.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:30:47.838.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMehdi Bouhaddou
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606; scientific name: Severe acute respiratory syndrome coronavirus 2; NCBI TaxID: 2697049;
ModificationListphosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos; Q Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-09-17 15:10:34ID requested
12024-02-15 17:50:26announced
22024-10-22 06:30:48announced2024-10-22: Updated project metadata.
Publication List
Kehrer T, Cupic A, Ye C, Yildiz S, Bouhaddou M, Crossland NA, Barrall EA, Cohen P, Tseng A, Ç, a, ğ, atay T, Rathnasinghe R, Flores D, Jangra S, Alam F, Mena I, Aslam S, Saqi A, Rutkowska M, Ummadi MR, Pisanelli G, Richardson RB, Veit EC, Fabius JM, Soucheray M, Polacco BJ, Ak B, Marin A, Evans MJ, Swaney DL, Gonzalez-Reiche AS, Sordillo EM, van Bakel H, Simon V, Zuliani-Alvarez L, Fontoura BMA, Rosenberg BR, Krogan NJ, Martinez-Sobrido L, Garc, í, a-Sastre A, Miorin L, Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis. Cell Host Microbe, 31(10):1668-1684.e12(2023) [pubmed]
10.1016/j.chom.2023.08.003;
Keyword List
ProteomeXchange project tag: Sars-cov-2, Covid-19
submitter keyword: SARS-CoV-2, orf6, COVID, coronavirus, phosphoproteomics, infection, COVID-19
Contact List
Nevan J. Krogan
contact affiliationProfessor, Department of Cellular and Molecular Pharmacology
contact emailnevan.krogan@ucsf.edu
lab head
Mehdi Bouhaddou
contact affiliationUCSF
contact emailmehdibouhaddou@gmail.com
dataset submitter
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Dataset FTP location
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PRIDE project URI
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