PXD036821

PXD036821 is an original dataset announced via ProteomeXchange.

Title	The accessory protein ORF6 contributes to SARS-CoV-2 pathogenesis by regulating host and viral gene expression
Description	We generated a SARS-CoV-2 virus in the Wuhan background with a deletion of the Orf6 gene. We then performed mass spectrometry abundance proteomics and phosphoproteomics analysis of infected cells.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:30:47.838.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mehdi Bouhaddou
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606; scientific name: Severe acute respiratory syndrome coronavirus 2; NCBI TaxID: 2697049;
ModificationList	phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos; Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-09-17 15:10:34	ID requested
1	2024-02-15 17:50:26	announced
⏵ 2	2024-10-22 06:30:48	announced	2024-10-22: Updated project metadata.

Kehrer T, Cupic A, Ye C, Yildiz S, Bouhaddou M, Crossland NA, Barrall EA, Cohen P, Tseng A, Ç, a, ğ, atay T, Rathnasinghe R, Flores D, Jangra S, Alam F, Mena I, Aslam S, Saqi A, Rutkowska M, Ummadi MR, Pisanelli G, Richardson RB, Veit EC, Fabius JM, Soucheray M, Polacco BJ, Ak B, Marin A, Evans MJ, Swaney DL, Gonzalez-Reiche AS, Sordillo EM, van Bakel H, Simon V, Zuliani-Alvarez L, Fontoura BMA, Rosenberg BR, Krogan NJ, Martinez-Sobrido L, Garc, í, a-Sastre A, Miorin L, Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis. Cell Host Microbe, 31(10):1668-1684.e12(2023) [pubmed]

10.1016/j.chom.2023.08.003;

ProteomeXchange project tag: Sars-cov-2, Covid-19

submitter keyword: SARS-CoV-2, orf6, COVID, coronavirus, phosphoproteomics, infection, COVID-19

Nevan J. Krogan
contact affiliation	Professor, Department of Cellular and Molecular Pharmacology
contact email	nevan.krogan@ucsf.edu
lab head
Mehdi Bouhaddou
contact affiliation	UCSF
contact email	mehdibouhaddou@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/02/PXD036821

PRIDE project URI

• PRIDE
  1. PXD036821
     1. Label: PRIDE project
     2. Name: The accessory protein ORF6 contributes to SARS-CoV-2 pathogenesis by regulating host and viral gene expression