PXD036779

PXD036779 is an original dataset announced via ProteomeXchange.

Title	Suppression of the nucleic acid precursor ribose 5-phosphate by RNA-mediated antiviral immunity.
Description	We identify that the antiviral protein kinase PKR alters glycolysis. This response is found to be independent of the kinase’s established control of gene expression that is executed through phosphorylation of the Eukaryotic Translation Initiation Factor 2. Instead, a novel substrate is recognised within the pentose phosphate pathway. The kinase is shown to regulate the activity of an isomerase that produces ribose 5-phosphate, which is an essential precursor for a number of macromolecules, including Coenzyme A, FAD, ATP, and nucleotides.
HostingRepository	PRIDE
AnnounceDate	2024-08-09
AnnouncementXML	Submission_2024-08-09_02:55:12.299.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ralf Schittenhelm
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-09-17 02:39:21	ID requested
⏵ 1	2024-08-09 02:55:13	announced

Bhattacharjee P, Wang D, Anderson D, Buckler JN, de Geus E, Yan F, Polekhina G, Schittenhelm R, Creek DJ, Harris LD, Sadler AJ, The immune response to RNA suppresses nucleic acid synthesis by limiting ribose 5-phosphate. EMBO J, 43(13):2636-2660(2024) [pubmed]

10.1038/s44318-024-00100-w;

submitter keyword: metabolism, protein Kinase R PKR, ribose 5-phosphate isomerase,Antiviral immunity

Anthony Sadler
contact affiliation	Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research and Department of Molecular and Translational Sciences, Monash University, Clayton, Victoria, Australia.
contact email	Anthony.sadler@hudson.org.au
lab head
Ralf Schittenhelm
contact affiliation	Monash University
contact email	ralf.schittenhelm@monash.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD036779

PRIDE project URI

• PRIDE
  1. PXD036779
     1. Label: PRIDE project
     2. Name: Suppression of the nucleic acid precursor ribose 5-phosphate by RNA-mediated antiviral immunity.