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PXD036736 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCharacterization of Chemotherapy-treated PyMT Liver Matrisome
DescriptionMetastasis accounts for 90% of cancer-related deaths, yet the mechanisms by which cancer cells colonize secondary organs remain poorly understood. For breast cancer patients, metastasis to the liver is associated with poor prognosis and a median survival of 6 months. Standard of care is chemotherapy, but recurrence occurs in 30% of patients. Systemic chemotherapy has been shown to induce hepatotoxicity and fibrosis, but how chemotherapy impacts the composition of the liver extracellular matrix (ECM) remains unknown. Individual ECM proteins drive tumor cell proliferation and invasion, features that are essential for metastatic outgrowth in the liver. Here, we characterize the liver ECM of tumor-bearing mice treated with and without chemotherapy using the MMTV-PyMT transgenic model of breast cancer. We identify distinct drug-specific changes induced by commonly used cytotoxic chemotherapies. We identify Collagen V as an ECM protein that is more abundant in livers isolated from paclitaxel-treated mice and identify mechanisms of Collagen V driven invasion via ECM organization and signaling through α1β1 integrins.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJustinne Guarin
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-09-14 14:16:46ID requested
12022-10-05 07:51:45announced
Publication List
Guarin JR, Fatherree JP, Oudin MJ, Chemotherapy treatment induces pro-invasive changes in liver ECM composition. Matrix Biol, 112():20-38(2022) [pubmed]
Keyword List
submitter keyword: Liver metastasis, breast cancer, mouse
Contact List
Madeleine J Oudin
contact affiliationDepartment of Biomedical Engineering, Tufts University, United States
contact emailmadeleine.oudin@tufts.edu
lab head
Justinne Guarin
contact affiliationTufts University
contact emailjguari02@tufts.edu
dataset submitter
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Dataset FTP location
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