PXD036734

PXD036734 is an original dataset announced via ProteomeXchange.

Title	Flycodes enable preclinical analysis of dozens of antibodies using single cassette-dosed mice. Dataset 2/6
Description	During discovery and development of protein-based drugs, extensive animal testing is required for preclinical analysis of pharmacokinetics, tissue biodistribution, toxicity, etc. Generally, several animals are required for testing a single drug. We show that the use of genetically encoded peptide barcodes, called flycodes, allows for the simultaneous preclinical assessment of dozens of antibodies from single cassette-dosed mice. Datasets: 1. comparison of flycodes vs. unique endogenous tryptic peptides for antibody identification 2. antibody PK, cassette dose A (high dose) 3. antibody PK, cassette dose B (low dose) 4. antibody tumor/organ biodistribution 5. Dar-SB thermostability 6. Dar-SB PK
HostingRepository	PRIDE
AnnounceDate	2025-02-26
AnnouncementXML	Submission_2025-02-26_07:11:16.592.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Justin Walter
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	deamidated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2022-09-14 14:14:35	ID requested
⏵ 1	2025-02-26 07:11:16	announced

Dataset with its publication pending

submitter keyword: drug development,antibodies, peptide barcodes, cassette dosing

Markus Seeger
contact affiliation	Institute of Medical Microbiology, University of Zurich
contact email	m.seeger@imm.uzh.ch
lab head
Justin Walter
contact affiliation	Institute for Medical Microbiology, University of Zurich
contact email	justindwalter@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/02/PXD036734

PRIDE project URI

• PRIDE
  1. PXD036734
     1. Label: PRIDE project
     2. Name: Flycodes enable preclinical analysis of dozens of antibodies using single cassette-dosed mice. Dataset 2/6