PXD036723

PXD036723 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of hippocampal proteins in moderate hepatic encephalopathy rat model
Description	Hepatic Encephalopathy is the brain disorder caused by liver damage, characterized by cognitive and motor impairments. Glutamate a predominant excitatory neurotransmitter over activate post-synaptic neuron via NMDAR receptors leads to neuronal derangement. NMDAR as a therapeutic target is not viable option due to its crucial role in brain physiology. In order to discover new non-NMDAR therapeutic targets high resolution mass spectrometry (HRMS) technique was used for proteomic profiling of the hippocampal proteins in Moderate hepatic encephalopathy (MoHE) rat model.
HostingRepository	PRIDE
AnnounceDate	2024-05-27
AnnouncementXML	Submission_2024-05-27_05:14:14.868.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Papia Acharjee
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	acetylated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-09-14 03:15:19	ID requested
⏵ 1	2024-05-27 05:14:15	announced

Prasad SK, Singh VV, Acharjee A, Acharjee P, Elucidating hippocampal proteome dynamics in moderate hepatic encephalopathy rats: insights from high-resolution mass spectrometry. Exp Brain Res, 242(7):1659-1679(2024) [pubmed]

10.1007/s00221-024-06853-4;

submitter keyword: hippocampus,Rat, hepatic encephalopathy, LC-MS/MS, label free

Papia Acharjee
contact affiliation	Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi-221005, India
contact email	pacharjee@bhu.ac.in
lab head
Papia Acharjee
contact affiliation	Institute of Science, Department of Zoology, Banaras Hindu University, Varanasi
contact email	pacharjee@bhu.ac.in
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD036723
     1. Label: PRIDE project
     2. Name: Proteomic analysis of hippocampal proteins in moderate hepatic encephalopathy rat model