PXD036706

PXD036706 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Metadata Entered in Submitting Proteomic Data to PRIDE
Description	For the identification of potential pathways and their interactions that underlie a complex change in cellular state, such as neurite outgrowth, we stimulated the neuroblastoma cell line N2A with HU210, a potent activator of the cannabinoid receptor type I, followed by transcriptomic and proteomic analysis. Differentially expressed genes and proteins obtained at multiple timepoints were subjected to standard and dynamic enrichment analysis using the Molecular Biology of the Cell Ontology. Many of the identified pathways described constitutive cellular functions. Involvement of predicted pathways in neurite outgrowth was confirmed by siRNA knock-down of pathway representative genes in primary rat cortical neurons. Dynamic modeling of pathway activities suggested that the identified increase in vesicle membrane back-transported from the growth cone to the cell body ensures recycling of components needed by forward moving vesicle.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:28:09.914.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD036706
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Yuguang Xiong
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	methylthiolated residue; acetylated residue; monohydroxylated residue
Instrument	LTQ Orbitrap Velos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-09-14 02:36:32	ID requested
1	2022-10-14 00:14:51	announced
⏵ 2	2023-11-14 08:28:10	announced	2023-11-14: Updated project metadata.

Publication List

10.6019/PXD036706;
Hansen J, Siddiq MM, Yadaw AS, Tolentino RE, Rabinovich V, Jayaraman G, Jain MR, Liu T, Li H, Xiong Y, Goldfarb J, Iyengar R, Whole cell response to receptor stimulation involves many deep and distributed subcellular biochemical processes. J Biol Chem, 298(10):102325(2022) [pubmed]

10.6019/PXD036706;

Hansen J, Siddiq MM, Yadaw AS, Tolentino RE, Rabinovich V, Jayaraman G, Jain MR, Liu T, Li H, Xiong Y, Goldfarb J, Iyengar R, Whole cell response to receptor stimulation involves many deep and distributed subcellular biochemical processes. J Biol Chem, 298(10):102325(2022) [pubmed]

Keyword List

submitter keyword: subcellular pathways
transcriptomics
Bioinformatics
dynamical modeling
neurite outgrowth
systems biology

submitter keyword: subcellular pathways

transcriptomics

Bioinformatics

dynamical modeling

neurite outgrowth

systems biology

Contact List

Ravi Iyengar
contact affiliation	Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
contact email	ravi.iyengar@mssm.edu
lab head
Yuguang Xiong
contact affiliation	Icahn School of Medicine at Mount Sinai
contact email	yuguang.xiong@mssm.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD036706
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD036706

PRIDE project URI

Repository Record List

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