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PXD036703

PXD036703 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleS-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons
DescriptionHere, we used a method, SNO trapping by triaryl phosphine (SNOTRAP), combined with mass spectrometry, to identify SNO-proteins present in post-mortem brain samples. Following analysis of SNO-proteins in samples of 11 human brains from patients LBD and controls, we detected 943 SNO-proteins and 1,552 SNO-sites, covering a wide range of the SNO proteome.
HostingRepositoryPRIDE
AnnounceDate2024-10-17
AnnouncementXMLSubmission_2024-10-17_03:12:22.529.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterHongmei Yang
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-09-14 02:24:31ID requested
12024-10-17 03:12:23announced
Publication List
10.1016/j.chembiol.2023.06.018;
Doulias PT, Yang H, Andreyev AY, Dolatabadi N, Scott H, K Raspur C, Patel PR, Nakamura T, Tannenbaum SR, Ischiropoulos H, Lipton SA, S-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons. Cell Chem Biol, 30(8):965-975.e6(2023) [pubmed]
Keyword List
ProteomeXchange project tag: Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project
submitter keyword: LBD,human brain, SNOTRAP
Contact List
Hongmei Yang
contact affiliationMIT
contact emailyanghm@mit.edu
lab head
Hongmei Yang
contact affiliationMIT
contact emailyanghm@mit.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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