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PXD036691

PXD036691 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe effects of silencing PTX3 oin the proteome of human endothelial cells
DescriptionThe human long pentraxin PTX3 has complex regulatory roles at the crossroad of innate immunity, inflammation, and tissue repair. PTX3 can be produced by various cell types, including vascular endothelial cells (ECs), in response to pro-inflammatory cytokines or bacterial molecules. But PTX3 has also been involved in the regulation of cardiovascular biology, even if contrasting results have been so far provided in both preclinical and clinical research. Therefore, we compared the proteomic profiles of human ECs isolated from umbilical cords (Human Umbilical Vein ECs, HUVECs), and we identified 19 proteins more abundant in the proteome of control ECs and 23 proteins more expressed in PTX3 silenced cells.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_07:17:30.361.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD036691
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterMaura Brioschi
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentSynapt MS
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-09-13 05:30:36ID requested
12023-03-10 20:17:20announced
22023-11-14 07:17:31announced2023-11-14: Updated project metadata.
Publication List
Banfi C, Brioschi M, Vicentini LM, Cattaneo MG, The Effects of Silencing PTX3 on the Proteome of Human Endothelial Cells. Int J Mol Sci, 23(21):(2022) [pubmed]
10.6019/PXD036691;
Keyword List
submitter keyword: endothelial cells, label-free mass spectrometry,PTX3
Contact List
Cristina Banfi
contact affiliationUnit of functional proteomic, metabolomi and network analysis, Centro Cardiologico Monzino IRCCS, Milan, Italy
contact emailcristina.banfi@cardiologicomonzino.it
lab head
Maura Brioschi
contact affiliationUnit of Proteomics- Centro Cardiologico Monzino IRCCS
contact emailmaura.brioschi@ccfm.it
dataset submitter
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Dataset FTP location
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