PXD036691 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | The effects of silencing PTX3 oin the proteome of human endothelial cells |
Description | The human long pentraxin PTX3 has complex regulatory roles at the crossroad of innate immunity, inflammation, and tissue repair. PTX3 can be produced by various cell types, including vascular endothelial cells (ECs), in response to pro-inflammatory cytokines or bacterial molecules. But PTX3 has also been involved in the regulation of cardiovascular biology, even if contrasting results have been so far provided in both preclinical and clinical research. Therefore, we compared the proteomic profiles of human ECs isolated from umbilical cords (Human Umbilical Vein ECs, HUVECs), and we identified 19 proteins more abundant in the proteome of control ECs and 23 proteins more expressed in PTX3 silenced cells. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_07:17:30.361.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD036691 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Maura Brioschi |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Synapt MS |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-09-13 05:30:36 | ID requested | |
1 | 2023-03-10 20:17:20 | announced | |
⏵ 2 | 2023-11-14 07:17:31 | announced | 2023-11-14: Updated project metadata. |
Publication List
Banfi C, Brioschi M, Vicentini LM, Cattaneo MG, The Effects of Silencing PTX3 on the Proteome of Human Endothelial Cells. Int J Mol Sci, 23(21):(2022) [pubmed] |
10.6019/PXD036691; |
Keyword List
submitter keyword: endothelial cells, label-free mass spectrometry,PTX3 |
Contact List
Cristina Banfi |
contact affiliation | Unit of functional proteomic, metabolomi and network analysis, Centro Cardiologico Monzino IRCCS, Milan, Italy |
contact email | cristina.banfi@cardiologicomonzino.it |
lab head | |
Maura Brioschi |
contact affiliation | Unit of Proteomics- Centro Cardiologico Monzino IRCCS |
contact email | maura.brioschi@ccfm.it |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD036691
- Label: PRIDE project
- Name: The effects of silencing PTX3 oin the proteome of human endothelial cells