PXD036685

PXD036685 is an original dataset announced via ProteomeXchange.

Title	Identification of the Key Protein Associated with Different Hair Types in Sheep and Goat
Description	Animal-derived fiber has the characteristics of being light, soft, strong, elastic and a good thermal insulator and it is widely used in many industries and traditional products, so it plays an important role in the economy of some countries. Variations among phenotypes of wool fibers, among species and breeds, are important for industry. We found the mean fiber diameter of cashmere was significantly smaller than sheep wool ( P < 0.01 ), and sheep wool was significantly smaller than goat wool ( P < 0.01 ). Compared with the traditional proteomics technology, we analyzed cashmere, Guard hair, and wool by Laber-free proteomics technology and detected 159, 204, and 70 proteins respectively. Through the sequential windowed acquisition of all theoretical fragmentations (SWATH), 41 and 54 differentially expressed proteins were successfully detected in the three type fibers. Protein-protein interaction network analysis of differentially expressed proteins revealed many strong interactions related to KRT85、KRTAP15-1 and KRTAP3-1. The final analysis showed that the proportion of KRT85、KRTAP15-1 and KRTAP3-1 might be the key protein leading to the difference in fiber diameter and could be used as a potential molecular marker for distinguishing different fiber types.
HostingRepository	iProX
AnnounceDate	2022-09-09
AnnouncementXML	Submission_2022-12-24_21:01:09.959.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chongyan Zhang
SpeciesList	scientific name: Capra hircus; NCBI TaxID: 9925; scientific name: Ovis aries; NCBI TaxID: 9940;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2022-09-12 19:41:30	ID requested
1	2022-09-20 19:36:05	announced
⏵ 2	2022-12-24 21:01:12	announced	2022-12-25: Update publication information.

Zhang C, Qin Q, Liu Z, Xu X, Lan M, Xie Y, Wang Z, Li J, Liu Z, Identification of the key proteins associated with different hair types in sheep and goats. Front Genet, 13():993192(2022) [pubmed]

submitter keyword: cashmere, sheep, proteomics, KRT, KRTAP

Zhihong Liu
contact affiliation	Inner+MongoliaAgricultural+University
contact email	liuzh7799@163.com
lab head
Chongyan Zhang
contact affiliation	Inner+MongoliaAgricultural+University
contact email	zhangcy9753@163.com
dataset submitter

iProX dataset URI