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PXD036676

PXD036676 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleStaphylococcus aureus prophage-encoded protein causes abortive infection and provides population immunity against kayviruses
DescriptionThe aim of the study was to investigate the resistance mechanism of Staphylococcus aureus towards lytic phages of the genus Kayvirus and the role of the membrane-anchored protein (primary accession Q2FYE0) designated PdpSau encoded by Staphylococcus aureus prophages. PdpSau does not prevent the infecting kayvirus from adsorbing onto the host cell and delivering its genome into the cell, but phage DNA replication is halted. Changes in the cell membrane polarity and permeability were observed 10 min after the infection leading to prophage-activated cell death. The LC-MS/MS analysis, as one of the methods, was used for protein detection and to find out whether this protein is predominantly presented in membranes. These findings are relevant for the advancement of phage therapy.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:59:01.563.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterPetr Gintar
SpeciesList scientific name: Staphylococcus aureus; NCBI TaxID: 1280;
ModificationListacetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-09-12 06:45:39ID requested
12023-02-03 07:24:56announced
22023-11-14 08:59:02announced2023-11-14: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Kayvirus, PdpSau, Phage resistance, Orbitrap,Staphylococcus aureus, LC-MS/MS
Contact List
Zbynek Zdrahal
contact affiliationCEITEC Masaryk university
contact emailzdrahal@sci.muni.cz
lab head
Petr Gintar
contact affiliationCEITEC
contact email460366@muni.cz
dataset submitter
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Dataset FTP location
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