The ubiquitome dataset by imputing missing values and normalization of 6844 ubiquitin modified peptides, 7026 lysine ubiquitination (Kub) site were defined in 2720 proteins, of which 3718 Kub site in 1379 proteins were quantified. Among these quantified Kub sites and proteins, 139 sites in 100 proteins were identified as upregulated ubiquitination sites, and 55 sites in 48 proteins were identified as downregulated ubiquitination sites at a threshold of 1.5 (P < 0.05)