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PXD036661

PXD036661 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleFlycodes enable preclinical analysis of dozens of antibodies using single cassette-dosed mice. Dataset 3/6
DescriptionDuring discovery and development of protein-based drugs, extensive animal testing is required for preclinical analysis of pharmacokinetics, tissue biodistribution, toxicity, etc. Generally, several animals are required for testing a single drug. We show that the use of genetically encoded peptide barcodes, called flycodes, allows for the simultaneous preclinical assessment of dozens of antibodies from single cassette-dosed mice. Datasets: 1. comparison of flycodes vs. unique endogenous tryptic peptides for antibody identification 2. antibody PK, cassette dose A (high dose) 3. antibody PK, cassette dose B (low dose) 4. antibody tumor/organ biodistribution 5. Dar-SB thermostability 6. Dar-SB PK
HostingRepositoryPRIDE
AnnounceDate2025-02-26
AnnouncementXMLSubmission_2025-02-26_06:50:20.248.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJustin Walter
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListdeamidated residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-09-12 06:31:52ID requested
12025-02-26 06:50:20announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: drug development,antibodies, peptide barcodes, cassette dosing
Contact List
Markus Seeger
contact affiliationInstitute of Medical Microbiology, University of Zurich
contact emailm.seeger@imm.uzh.ch
lab head
Justin Walter
contact affiliationInstitute for Medical Microbiology, University of Zurich
contact emailjustindwalter@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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