PXD036588

PXD036588 is an original dataset announced via ProteomeXchange.

Title	Quantitative proteomics characterization on the effect and mechanism of trichostatin A on hippocampus of type II diabetic mice
Description	Cognitive dysfunction is the main feature of diabetic encephalopathy (DE). The effect and mechanism of trichostatin A (TSA) on cognitive function of diabetic mice is not elucidated. Our study revealed the key pathways and vital hubgenes of the effect of TSA on hippocampus of type II diabetic mice, including longevity regulating pathway, peroxisome, ribosome, protein processing in endoplasmic reticulum, insulin signaling pathway, CAT and PRKAA2. As well, GSK-1059615, alisertib and avrainvillamide-analog-6 were suggested to be the promising ancillary intervention drugs for diabetic encephalopathy.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_09:26:54.840.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dezhi Kong
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-09-08 07:09:36	ID requested
⏵ 1	2025-05-06 09:26:55	announced

10.1007/s10571-023-01424-7;

Wei W, Zhang Q, Jin T, Zhu L, Zhao J, Li F, Zhao S, Kong D, Hao J, Quantitative Proteomics Characterization of the Effect and Mechanism of Trichostatin A on the Hippocampus of Type II Diabetic Mice. Cell Mol Neurobiol, 43(8):4309-4332(2023) [pubmed]

submitter keyword: proteomics, diabetic encephalopathy, cognitive function, drug screening,Trichostatin A

Dezhi Kong
contact affiliation	School of Chinese Integrative Medicine,Hebei Medical University,Shijiazhuang,China
contact email	kongdezhi@hebmu.edu.cn
lab head
Dezhi Kong
contact affiliation	Hebei medical university
contact email	kongdezhi@hebmu.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD036588

PRIDE project URI

• PRIDE
  1. PXD036588
     1. Label: PRIDE project
     2. Name: Quantitative proteomics characterization on the effect and mechanism of trichostatin A on hippocampus of type II diabetic mice